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首页> 美国卫生研究院文献>Scientific Reports >Comprehensive rehabilitation with integrative medicine for subacute stroke: A multicenter randomized controlled trial
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Comprehensive rehabilitation with integrative medicine for subacute stroke: A multicenter randomized controlled trial

机译：亚急性脑卒中中西医结合综合康复：多中心随机对照试验

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To determine whether integrative medicine rehabilitation (IMR) that combines conventional rehabilitation (CR) with acupuncture and Chinese herbal medicine has better effects for subacute stroke than CR alone, we conducted a multicenter randomized controlled trial that involved three hospitals in China. Three hundred sixty patients with subacute stroke were randomized into IMR and CR groups. The primary outcome was the Modified Barthel Index (MBI). The secondary outcomes were the National Institutes of Health Stroke Scale (NIHSS), the Fugl-Meyer Assessment (FMA), the mini-mental state examination (MMSE), the Montreal Cognitive Assessment (MoCA), Hamilton’s Depression Scale (HAMD), and the Self-Rating Depression Scale (SDS). All variables were evaluated at week 0 (baseline), week 4 (half-way of intervention), week 8 (after treatment) and week 20 (follow-up). In comparison with the CR group, the IMR group had significantly better improvements (P < 0.01 or P < 0.05) in all the primary and secondary outcomes. There were also significantly better changes from baseline in theses outcomes in the IMR group than in the CR group (P < 0.01). A low incidence of adverse events with mild symptoms was observed in the IMR group. We conclude that conventional rehabilitation combined with integrative medicine is safe and more effective for subacute stroke rehabilitation.
机译：为了确定将传统康复（CR）与针灸和中草药相结合的中医康复（IMR）是否比仅采用CR的亚急性中风效果更好，我们进行了一项涉及中国三家医院的多中心随机对照试验。将360例亚急性中风患者随机分为IMR和CR组。主要结局是改良Barthel指数（MBI）。次要结果是美国国立卫生研究院卒中量表（NIHSS），Fugl-Meyer评估（FMA），小精神状态检查（MMSE），蒙特利尔认知评估（MoCA），汉密尔顿抑郁量表（HAMD）和自评抑郁量表（SDS）。在第0周（基线），第4周（干预的一半），第8周（治疗后）和第20周（随访）评估所有变量。与CR组相比，IMR组在所有主要和次要结局方面均有显着改善（P <0.01或P <0.05）。与CR组相比，IMR组的这些结局与基线相比有显着更好的变化（P <0.01）。在IMR组中，观察到具有轻度症状的不良事件发生率低。我们得出的结论是，常规康复结合中西医结合治疗对于亚急性中风康复是安全且有效的。

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