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Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy

机译：向糖尿病db / db小鼠施用丹红注射液可抑制糖尿病性视网膜病变和肾病的发展

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Danhong Injection (DHI), a Chinese medicine for treatment of patients with coronary heart disease, inhibits primary abdominal aortic aneurysms in apoE deficient (apoE>−/−) mice. Formation of microaneurysms plays an important role in the development of diabetic retinopathy and nephropathy. It remains unknown if DHI can reduce these diabetic complications. In this study, diabetic db/db mice in two groups were injected with saline and DHI, respectively, for 14 weeks. Blood and tissue samples were collected to determine serum glucose, lipids and tissue structure. DHI reduced diabetes-induced body weight gain, serum cholesterol and glucose levels. In retinas, DHI blocked the shrink of whole retina and retinal sub-layers by inhibiting expression of caspase 3, matrix metalloproteinase 2 (MMP-2) and MMP-9, accumulation of carbohydrate macromolecules and formation of acellular capillaries. DHI improved renal functions by inhibiting mesangial matrix expansion, expression of vascular endothelial growth factor A, fibronectin and advanced glycation end products in kidneys. Mechanistically, DHI induced expression of glucokinase, AMPKα/phosphorylated AMPKα, insulin receptor substrate 1, fibroblast growth factor 21 and peroxisome proliferator-activated γ. Expression of genes responsible for energy expenditure was also activated by DHI. Therefore, DHI inhibits diabetic retinopathy and nephropathy by ameliorating glucose metabolism and demonstrates a potential application in clinics.
机译：丹红注射液（DHI）是一种治疗冠心病患者的中药，可抑制apoE缺陷（apoE >-// ）小鼠的原发性腹主动脉瘤。微动脉瘤的形成在糖尿病性视网膜病和肾病的发展中起重要作用。 DHI是否可以减轻这些糖尿病并发症仍然未知。在这项研究中，两组的db / db糖尿病小鼠分别注射了生理盐水和DHI，持续14周。收集血液和组织样本以确定血清葡萄糖，脂质和组织结构。 DHI降低了糖尿病引起的体重增加，血清胆固醇和葡萄糖水平。在视网膜中，DHI通过抑制caspase 3，基质金属蛋白酶2（MMP-2）和MMP-9的表达，碳水化合物大分子的积累和无细胞毛细血管的形成来阻止整个视网膜和视网膜亚层的收缩。 DHI通过抑制肾小球系膜基质扩张，血管内皮生长因子A，纤连蛋白和晚期糖基化终产物的表达来改善肾脏功能。从机理上讲，DHI诱导了葡萄糖激酶，AMPKα/磷酸化的AMPKα，胰岛素受体底物1，成纤维细胞生长因子21和过氧化物酶体增殖物激活的γ的表达。 DHI也激活了负责能量消耗的基因的表达。因此，DHI通过改善葡萄糖代谢来抑制糖尿病性视网膜病和肾病，并显示出在临床中的潜在应用。

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