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首页> 美国卫生研究院文献>Journal of Korean Medical Science >Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
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Measurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis

机译：类风湿关节炎患者白细胞介素33（IL-33）和IL-33受体（sST2和ST2L）的测量

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The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, P = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (P = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (r = 0.311, P = 0.005), and IL-33 and IL-6 (r = 0.264, P = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.
机译：白介素33（IL-33）/ ST2途径已作为参与抗原-过敏原反应，自身免疫和纤维化的细胞间信号系统出现。已经提出IL-33 / ST2信号转导已参与类风湿关节炎（RA）的发病机理，因为IL-33及其受体已被特异性地定位于RA滑膜。这项研究的目的是确定RA患者血清和滑液中IL-33和sST2的水平。 RA患者的血清IL-33水平显着高于健康对照组（96.0±236.9 pg / mL，P = 0.002）（294.9±464.0 pg / mL）。 RA患者的滑液IL-33水平明显高于骨关节炎患者。 RA患者的血清sST2水平高于健康对照组（P = 0.042）。在81例RA患者中，IL-33和IL-1β水平（r = 0.311，P = 0.005）与IL-33和IL-6水平（r = 0.264，P = 0.017）之间存在显着关系。在常规的改变病情的抗风湿药治疗后，10例初治RA的患者IL-33，sST2和C反应蛋白的水平降低。最终，IL-33参与了RA的发病机制，可能反映了RA患者的炎症程度。

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