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首页> 美国卫生研究院文献>Journal of Lipid Research >Effects of Therapeutic Lifestyle Change diets high and low in dietaryfish-derived FAs on lipoprotein metabolism in middle-aged and elderlysubjects
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Effects of Therapeutic Lifestyle Change diets high and low in dietaryfish-derived FAs on lipoprotein metabolism in middle-aged and elderlysubjects

机译：治疗生活方式的影响改变饮食中高低饮食鱼衍生脂肪酸对中老年人脂蛋白代谢的影响科目

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The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23%), production rate (PR, −9%), and direct catabolism (−53%), and increased TRL-to-LDL apoB-100 conversion (+39%) as compared with the baseline diet (all P < 0.05). This diet also decreased TRL apoB-48 concentration (−24%), fractional catabolic rate (FCR, −20%), and PR (−50%) as compared with the baseline diet (all P < 0.05). The high-fish and low-fish diets decreased LDL apoB-100 concentration (−9%, −23%), increased LDL apoB-100 FCR (+44%, +48%), and decreased HDL apoA-I concentration (−15%, −14%) and PR (−11%, −12%) as compared with the baseline diet (all P < 0.05). On the high-fish diet, changes in TRL apoB-100 PR were negatively correlated with changes in plasma eicosapentaenoic and docosahexaenoic acids. In conclusion, thehigh-fish diet decreased TRL apoB-100 and TRL apoB-48 concentrations chiefly bydecreasing their PR. Both diets decreased LDL apoB-100 concentration by increasingLDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-IPR.
机译：研究了饮食鱼的高低饮食治疗生活方式改变（TLC）饮食对载脂蛋白代谢的影响。为受试者提供西餐饮食6周，然后提供两种TLC饮食中的任何一种饮食24周（10次/组）。在每个阶段结束时，使用稳定的同位素方法和区室模型在进食状态下测定载脂蛋白动力学。只有高鱼饮食降低了富含甘油三酸酯的脂蛋白（TRL）的apoB-100浓度中位数（−23％），生产率（PR，−9％）和直接分解代谢（−53％），并增加了TRL至与基线饮食相比，LDL apoB-100转化率（+39％）（所有P <0.05）。与基线饮食相比，该饮食还降低了TRL apoB-48浓度（−24％），分解代谢率（FCR，−20％）和PR（−50％）（所有P <0.05）。高鱼和低鱼饮食降低LDL apoB-100浓度（−9％，−23％），增加LDL apoB-100 FCR（+44％，+ 48％）和降低HDL apoA-I浓度（−与基线饮食相比（分别为15％，-14％）和PR（-11％，-12％）（所有P <0.05）。在高鱼饮食中，TRL apoB-100 PR的变化与血浆二十碳五烯酸和二十二碳六烯酸的变化呈负相关。总之，高鱼饮食主要通过以下方式降低TRL apoB-100和TRL apoB-48的浓度降低他们的公关两种饮食均通过增加LDL apoB-100浓度而降低LDL apoB-100 FCR和通过降低HDL apoA-I降低HDL apoA-I浓度公关

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