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GO annotation in InterPro: why stability does not indicate accuracy in a sea of changing annotations

机译:InterPro中的GO批注:为什么在不断变化的批注中稳定性不能表示准确性

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摘要

The removal of annotation from biological databases is often perceived as an indicator of erroneous annotation. As a corollary, annotation stability is considered to be a measure of reliability. However, diverse data-driven events can affect the stability of annotations in both primary protein sequence databases and the protein family databases that are built upon the sequence databases and used to help annotate them. Here, we describe some of these events and their consequences for the InterPro database, and demonstrate that annotation removal or reassignment is not always linked to incorrect annotation by the curator.>Database URL:
机译:从生物学数据库中删除注释通常被视为错误注释的指示。因此,注释稳定性被认为是对可靠性的一种度量。但是,各种数据驱动的事件可能会影响一级蛋白质序列数据库和建立在序列数据库上并用于帮助对其进行注释的蛋白质家族数据库中注释的稳定性。在这里,我们描述了其中一些事件及其对InterPro数据库的影响,并说明了注释的删除或重新分配并不总是与策展人链接到错误的注释有关。>数据库URL:

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