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ProteomeScout: a repository and analysis resource for post-translational modifications and proteins

机译:ProteomeScout:用于翻译后修饰和蛋白质的存储库和分析资源

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摘要

ProteomeScout () is a resource for the study of proteins and their post-translational modifications (PTMs) consisting of a database of PTMs, a repository for experimental data, an analysis suite for PTM experiments, and a tool for visualizing the relationships between complex protein annotations. The PTM database is a compendium of public PTM data, coupled with user-uploaded experimental data. ProteomeScout provides analysis tools for experimental datasets, including summary views and subset selection, which can identify relationships within subsets of data by testing for statistically significant enrichment of protein annotations. Protein annotations are incorporated in the ProteomeScout database from external resources and include terms such as Gene Ontology annotations, domains, secondary structure and non-synonymous polymorphisms. These annotations are available in the database download, in the analysis tools and in the protein viewer. The protein viewer allows for the simultaneous visualization of annotations in an interactive web graphic, which can be exported in Scalable Vector Graphics (SVG) format. Finally, quantitative data measurements associated with public experiments are also easily viewable within protein records, allowing researchers to see how PTMs change across different contexts. ProteomeScout should prove useful for protein researchers and should benefit the proteomics community by providing a stable repository for PTM experiments.
机译:ProteomeScout()是研究蛋白质及其翻译后修饰(PTM)的资源,包括PTM数据库,实验数据存储库,PTM实验分析套件以及可视化复杂蛋白质之间关系的工具注释。 PTM数据库是公共PTM数据以及用户上传的实验数据的汇编。 ProteomeScout提供了用于实验数据集的分析工具,包括摘要视图和子集选择,这些工具可以通过测试蛋白质注释的统计学显着丰富性来识别数据子集中的关系。蛋白质注释从外部资源整合到ProteomeScout数据库中,包括诸如基因本体注释,域,二级结构和非同义词多态性之类的术语。这些注释可在数据库下载,分析工具和蛋白质查看器中找到。蛋白质查看器允许在交互式Web图形中同时可视化注释,该图形可以以可缩放矢量图形(SVG)格式导出。最后,与公共实验相关的定量数据测量结果也可以在蛋白质记录中轻松查看,从而使研究人员能够了解PTM在不同情况下的变化。 ProteomeScout应该被证明对蛋白质研究人员有用,并且应该通过为PTM实验提供一个稳定的存储库来使蛋白质组学界受益。

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