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首页> 外文期刊>Current Protocols in Bioinformatics >Using ProteomeScout: A Resource of Post-Translational Modifications, Their Experiments, and the Proteins That They Annotate
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Using ProteomeScout: A Resource of Post-Translational Modifications, Their Experiments, and the Proteins That They Annotate

机译：使用proteomescout：翻译后修饰的资源，他们的实验和它们注释的蛋白质

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摘要

Post-translational modifications (PTMs) of protein amino acids are ubiquitous and important to protein function, localization, degradation, and more. In recent years, there has been an explosion in the discovery of PTMs as a result of improvements inPTM measurement techniques, including quantitative measurements of PTMs across multiple conditions. ProteomeScout is a repository for such discovery and quantitative experiments and provides tools for visualizing PTMs within proteins, including where they are relative to other PTMS, domains, mutations, and structure. ProteomeScout additionally provides analysis tools for identifying statistically significant relationships in experimental datasets. This unit describes four basic protocols for working with the Pro-teomeScout Web interface or programmatically with the database download.
机译：蛋白质氨基酸的翻译后修饰（PTMS）对蛋白质功能，局部化，降解等至关重要。 近年来，由于改进了ONPTM测量技术，在PTMS发现中存在爆炸，包括多种条件的PTMS的定量测量。 Proteomescout是用于这种发现和定量实验的储存库，并提供用于在蛋白质中可视化PTM的工具，包括它们相对于其他PTM，结构域，突变和结构。 Proteomescout还提供了用于识别实验数据集中统计上显着关系的分析工具。 本机描述了四种基本协议，用于使用Pro-TeoMescout Web界面或以编程方式使用数据库下载。

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