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首页> 美国卫生研究院文献>Nucleic Acids Research >ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms
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ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms

机译：ADReCS：一个本体数据库用于辅助药物不良反应术语的标准化和分级分类

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摘要

Adverse drug reactions (ADRs) are noxious and unexpected effects during normal drug therapy. They have caused significant clinical burden and been responsible for a large portion of new drug development failure. Molecular understanding and in silico evaluation of drug (or candidate) safety in laboratory is thus so desired, and unfortunately has been largely hindered by misuse of ADR terms. The growing impact of bioinformatics and systems biology in toxicological research also requires a specialized ADR term system that works beyond a simple glossary. Adverse Drug Reaction Classification System (ADReCS; ) is a comprehensive ADR ontology database that provides not only ADR standardization but also hierarchical classification of ADR terms. The ADR terms were pre-assigned with unique digital IDs and at the same time were well organized into a four-level ADR hierarchy tree for building an ADR–ADR relation. Currently, the database covers 6544 standard ADR terms and 34 796 synonyms. It also incorporates information of 1355 single active ingredient drugs and 134 022 drug–ADR pairs. In summary, ADReCS offers an opportunity for direct computation on ADR terms and also provides clues to mining common features underlying ADRs.
机译：药物不良反应（ADR）在正常药物治疗期间具有有害和意料之外的作用。它们造成了巨大的临床负担，并导致了很大一部分新药开发失败。因此，需要在实验室中对药物（或候选药物）的安全性进行分子理解和计算机分析，不幸的是，滥用ADR术语在很大程度上阻碍了这种理解。生物信息学和系统生物学在毒理学研究中日益增长的影响还需要专门的ADR术语系统，其作用范围超出简单的词汇表。药品不良反应分类系统（ADReCS;）是一个全面的ADR本体数据库，不仅提供ADR标准化，还提供ADR术语的层次分类。 ADR术语已预先分配了唯一的数字ID，并同时被很好地组织成四级ADR层次树，以建立ADR-ADR关系。目前，该数据库涵盖6544个标准ADR术语和34 796个同义词。它还包含了1355种单一有效成分药物和134 022种药物-ADR对的信息。总之，ADReCS提供了直接根据ADR条款进行计算的机会，并且还提供了挖掘ADR底层常见功能的线索。

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