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首页> 外文会议>Conference on Data Mining, Systems Analysis, and Optimization in Biomedicine >Adverse drag reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reac
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Adverse drag reactions (ADRs) are estimated to be one of the leading causes of death. Many national and international agencies have set up databases of ADR reports for the express purpose of determining the relationship between drugs and adverse reac

机译：估计不良反应（ADR）是成为死亡原因之一。许多国家和国际代理商已经建立了ADR报告的数据库，以确定药物与不良核心之间的关系

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摘要

Cellular stress activates transcription of various genes that mediate stress-driven proliferation and differentiation in many cells including osteoblasts, endothelial cells, and fibroblasts. In response to mechanical stress, expression of some genes is altered regardless of cell types and that of others in specific cell types. Using the microarray-based expression data for primary fibroblasts isolated from fetal mouse cornea, skin and tendon, we conducted a model-based transcription analysis and predicted transcription-factor binding motifs (TFBMs) responsible for the observed gene alteration. The computational procedure was formulated as a combinatorial optimization problem, and the AntModeler using an ant algorithm was employed to select TFBMs for each of the three fibroblast types. The results indicate that the stress responses are regulated mostly through cell type specific TFBMs together with a limited number of common TFBMs. The predicted role of those TFBMs should be evaluated experimentally.
机译：细胞应激激活各种基因的转录，其在许多细胞中介导应力驱动的增殖和分化，包括成骨细胞，内皮细胞和成纤维细胞。响应于机械应力，无论细胞类型和特定细胞类型中的其他基因如何，都会改变一些基因的表达。利用从胎儿小鼠角膜，皮肤和肌腱分离的初生成纤维细胞的基于微阵列的表达数据，我们进行了一种基于模型的转录分析和预测转录因子结合基序（TFBMS），其负责观察到的基因变化。将计算过程配制成组合优化问题，使用使用蚂蚁算法的antModeler为三种成纤维细胞类型中的每一个选择TFBMS。结果表明应力响应主要通过细胞类型特异性TFBMS调节，以及有限数量的常见TFBMS。应该通过实验评估这些TFBMS的预测作用。

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