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首页> 美国卫生研究院文献>Physiological Reports >Aspirate from human stented saphenous vein grafts induces epicardial coronary vasoconstriction and impairs perfusion and left ventricular function in rat bioassay hearts with pharmacologically induced endothelial dysfunction
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Aspirate from human stented saphenous vein grafts induces epicardial coronary vasoconstriction and impairs perfusion and left ventricular function in rat bioassay hearts with pharmacologically induced endothelial dysfunction

机译：在具有药理学上的内皮功能障碍的大鼠生物测定心脏中从带支架的大隐静脉移植物中吸出可引起心外膜冠状动脉收缩并损害灌注和左心室功能

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摘要

Stent implantation into aortocoronary saphenous vein grafts (SVG) releases particulate debris and soluble vasoactive mediators, for example, serotonin. We now analyzed effects of the soluble mediators released into the coronary arterial blood during stent implantation on vasomotion of isolated rat epicardial coronary artery segments and on coronary flow and left ventricular developed pressure in isolated perfused rat hearts. Coronary blood was retrieved during percutaneous SVG intervention using a distal occlusion/aspiration protection device in nine symptomatic patients with stable angina pectoris and a flow‐limiting SVG stenosis. The blood was separated into particulate debris and plasma. Responses to coronary plasma were determined in isolated rat epicardial coronary arteries and in isolated, constant pressure‐perfused rat hearts (±nitric oxide synthase [NOS] inhibition and ±serotonin receptor blockade, respectively). Coronary aspirate plasma taken after stent implantation induced a stronger vasoconstriction of rat epicardial coronary arteries (52 ± 8% of maximal potassium chloride induced vasoconstriction [% KClmax = 100%]) than plasma taken before stent implantation (12 ± 8% of KClmax); NOS inhibition augmented this vasoconstrictor response (to 110 ± 15% and 24 ± 9% of KClmax). Coronary aspirate plasma taken after stent implantation reduced in isolated perfused rat hearts only under NOS inhibition coronary flow by 17 ± 3% and left ventricular developed pressure by 25 ± 4%. Blockade of serotonin receptors abrogated these effects. Coronary aspirate plasma taken after stent implantation induces vasoconstriction in isolated rat epicardial coronary arteries and reduces coronary flow and left ventricular developed pressure in isolated perfused rat hearts with pharmacologically induced endothelial dysfunction.
机译：将支架植入主动脉大隐静脉移植物（SVG）中会释放颗粒碎片和可溶性血管活性介质，例如5-羟色胺。我们现在分析了在支架植入过程中释放到冠状动脉血液中的可溶性介体对离体大鼠心外膜冠状动脉节段的血管运动以及离体灌注大鼠心脏中冠状动脉血流和左心室发育压力的影响。在9名有稳定型心绞痛和限流性SVG狭窄的有症状患者中，使用远端闭塞/抽吸保护装置在经皮SVG干预期间回收了冠状动脉血。血液被分离成微粒碎片和血浆。在离体大鼠心外膜冠状动脉和离体恒压灌注大鼠心脏中确定对冠状动脉血浆的反应（分别抑制一氧化氮合酶[NOS]和阻断5-羟色胺受体）。支架植入后的冠状抽吸血浆诱导的大鼠心外膜冠状动脉血管收缩（最大氯化钾诱导的血管收缩的52±8％[％KClmax = 100％]）比支架植入前的血浆（12±8％KClmax）强; NOS抑制增强了这种血管收缩反应（达到KClmax的110±15％和24±9％）。仅在NOS抑制下，仅在NOS抑制的冠状动脉血流减少17±3％的情况下，在支架植入后取走的冠状抽吸血浆才减少。血清素受体的阻断消除了这些作用。支架植入后采集的冠状抽吸血浆在离体大鼠心外膜冠状动脉中引起血管收缩，并减少离体灌注的大鼠心脏中的药理学诱发的内皮功能障碍，从而降低冠状动脉血流量和左心室形成的压力。

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