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首页> 美国卫生研究院文献>Physiological Reports >Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise
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Acute supplementation of N‐acetylcysteine does not affect muscle blood flow and oxygenation characteristics during handgrip exercise

机译：急性补充N‐乙酰半胱氨酸不会影响手握锻炼期间的肌肉血流量和氧合特性

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N‐acetylcysteine (NAC; antioxidant and thiol donor) supplementation has improved exercise performance and delayed fatigue, but the underlying mechanisms are unknown. One possibility is NAC supplementation increases limb blood flow during severe‐intensity exercise. The purpose was to determine if NAC supplementation affected exercising arm blood flow and muscle oxygenation characteristics. We hypothesized that NAC would lead to higher limb blood flow and lower muscle deoxygenation characteristics during severe‐intensity exercise. Eight healthy nonendurance trained men (21.8 ± 1.2 years) were recruited and completed two constant power handgrip exercise tests at 80% peak power until exhaustion. Subjects orally consumed either placebo (PLA) or NAC (70 mg/kg) 60 min prior to handgrip exercise. Immediately prior to exercise, venous blood samples were collected for determination of plasma redox balance. Brachial artery blood flow (BABF) was measured via Doppler ultrasound and flexor digitorum superficialis oxygenation characteristics were measured via near‐infrared spectroscopy. Following NAC supplementaiton, plasma cysteine (NAC: 47.2 ± 20.3 μmol/L vs. PLA: 9.6 ± 1.2 μmol/L; P = 0.001) and total cysteine (NAC: 156.2 ± 33.9 μmol/L vs. PLA: 132.2 ± 16.3 μmol/L; P = 0.048) increased. Time to exhaustion was not significantly different (P = 0.55) between NAC (473.0 ± 62.1 sec) and PLA (438.7 ± 58.1 sec). Resting BABF was not different (P = 0.79) with NAC (99.3 ± 31.1  style="fixed-case">mL/min) and style="fixed-case">PLA (108.3 ± 46.0  style="fixed-case">mL/min). style="fixed-case">BABF was not different (P = 0.42) during exercise or at end‐exercise ( style="fixed-case">NAC: 413 ± 109  style="fixed-case">mL/min; style="fixed-case">PLA: 445 ± 147  style="fixed-case">mL/min). Deoxy‐[hemoglobin+myoglobin] and total‐[hemoglobin+myoglobin] were not significantly different (P = 0.73 and P = 0.54, respectively) at rest or during exercise between conditions. We conclude that acute style="fixed-case">NAC supplementation does not alter oxygen delivery during exercise in men.
机译：补充N-乙酰半胱氨酸（NAC；抗氧化剂和硫醇供体）可改善运动表现并延缓疲劳，但其潜在机制尚不清楚。一种可能是在剧烈运动中补充NAC会增加肢体血流量。目的是确定补充NAC是否会影响运动手臂的血流量和肌肉氧合特性。我们假设在剧烈运动中，NAC会导致肢体血流量增加和肌肉脱氧特性降低。招募了八名接受过非耐力训练的健康男性（21.8±1.2岁），并以80％的峰值功率完成了两个恒定功率的握力运动测试，直到筋疲力尽。受试者在手握运动前60分钟口服服用安慰剂（PLA）或NAC（70 mg / kg）。紧接运动前，收集静脉血样本以测定血浆氧化还原平衡。通过多普勒超声测量肱动脉血流量（BABF），并通过近红外光谱术测量浅指屈肌的氧合特性。补充NAC后，血浆半胱氨酸（NAC：47.2±20.3μmol/ L vs. PLA：9.6±1.2μmol/ L; P = 0.001）和总半胱氨酸（NAC：156.2±33.9μmol/ L vs. PLA：132.2±16.3μmol / L; P = 0.048）增加。 NAC（473.0±62.1秒）和PLA（438.7±58.1秒）之间的疲劳时间没有显着差异（P = 0.55）。静息BABF与NAC（99.3±31.1） style =“ fixed-case”> mL / min和 style =“ fixed-case”> PLA 相同（P = 0.79） （108.3±46.0 style =“ fixed-case”> mL / min）。 style =“ fixed-case”> BABF 在锻炼过程中或运动后（NAC ：413±109）相同（P = 0.42） style =“ fixed-case”> mL / min; style =“ fixed-case”> PLA ：445±147。 style =“ fixed-case”> mL / min）。休息或运动期间两种状态之间的脱氧[血红蛋白+肌红蛋白]和总[血红蛋白+肌红蛋白]无显着差异（分别为P = 0.73和P = 0.54）。我们得出结论，急性 style =“ fixed-case”> NAC 补充剂不会改变男性运动期间的氧气输送。

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