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Behavior-driven Arc expression is reduced in all ventral hippocampal subfields compared to CA1 CA3 and dentate gyrus in rat dorsal hippocampus

机译：与大鼠背侧海马中的CA1CA3和齿状回相比行为驱动的Arc表达在所有腹侧海马亚域均降低

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摘要

Anatomical connectivity and lesion studies reveal distinct functional heterogeneity along the dorsal-ventral axis of the hippocampus. The immediate early gene Arc is known to be involved in neural plasticity and memory and can be used as a marker for cell activity that occurs, for example, when hippocampal place cells fire. We report here, that Arc is expressed in a greater proportion of cells in dorsal CA1, CA3 and dentate gyrus (DG), following spatial behavioral experiences compared to ventral hippocampal subregions (dorsal CA1= 33%; ventral CA1= 13%; dorsal CA3 = 23%; ventral CA3 = 8%; and dorsal DG = 2.5%; ventral DG = 1.2%). The technique used here to obtain estimates of numbers of behavior-driven cells across the dorsal-ventral axis, however, corresponds quite well with samples from available single unit recording studies. Several explanations for the two-to-three-fold reduction in spatial behavior-driven cell activity in the ventral hippocampus can be offered. These include anatomical connectivity differences, differential gain of the self-motion signals that appear to alter the scale of place fields and the proportion of active cells, and possibly variations in the neuronal responses to non-spatial information within the hippocampus along its dorso-ventral axis.
机译：解剖学连通性和病变研究揭示了沿海马背腹轴的明显功能异质性。已知立即早期基因Arc与神经可塑性和记忆有关，并且可以用作细胞活动的标志物，例如在海马地方细胞着火时发生的活动。我们在这里报告说，相比于腹侧海马亚区（背侧CA1 = 33％；腹侧CA1 = 13％；背侧CA3），在空间行为经历后，弧在背侧CA1，CA3和齿状回（DG）的细胞中所占比例更高= 23％；腹侧CA3 = 8％；背侧DG = 2.5％；腹侧DG = 1.2％）。然而，这里用于获得横跨背腹轴的行为驱动细胞数量的估计的技术，与来自可用单单位记录研究的样本非常吻合。可以提供有关腹侧海马中空间行为驱动的细胞活动减少两到三倍的几种解释。这些包括解剖学上的连通性差异，似乎改变位置场的大小和活动细胞的比例的自运动信号的差异增益，以及海马沿背腹向非空间信息的神经元反应的变化。轴。

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