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The ventral hippocampal muscarinic cholinergic system plays a key role in sexual dimorphisms of spatial working memory in rats

机译：腹侧海马毒蕈碱胆碱能系统在大鼠空间工作记忆的性二态性中起关键作用

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Sex differences in cognitive processing and function have been documented in human and animal studies. Females have been found to perform better than males on non-spatial memory tasks, while males tend to outperform females on spatial memory tasks. The neural mechanisms underlying these sexual dimorphisms are unclear. However, it is known that the cholinergic system is critically involved in memory processes, and there are notable differences between males and females in cholinergic system function and receptor expression. In particular, there are sex differences in the processing of information in the frontal cortex and hippocampus. In this study, we examined the roles of muscarinic and nicotinic acetylcholine receptors in the medial frontal cortex (MfC) and ventral hippocampus (VH) on spatial working memory in male and female rats. Local infusions of scopolamine (SCOP) and mecamylamine (MEC) (10, 20, 50 µg/side) were used to antagonize these receptors in each respective brain region during performance in the 16-arm radial arm maze. Infusions of SCOP into the VH caused a significant increase in memory errors in female rats, but had no significant effect on males, while infusions of MEC into the VH had no effect on either sex. Infusions of both SCOP (50 µg/side) and MEC (20 µg/side) into the MfC caused working memory impairments in both sexes. These results show that muscarinic acetylcholine receptors in the VH are differentially vulnerable to spatial memory impairments in females. Ventral hippocampal muscarinic acetylcholine receptors may play a key role in male-female differences in spatial memory.
机译：在人类和动物研究中已记录了认知加工和功能方面的性别差异。发现女性在非空间记忆任务上的表现要好于男性，而男性在空间记忆任务上的表现往往优于女性。这些性二态性的潜在神经机制尚不清楚。然而，已知胆碱能系统关键地参与记忆过程，并且在胆碱能系统功能和受体表达方面，男性和女性之间存在显着差异。特别是，额叶皮层和海马中信息的处理存在性别差异。在这项研究中，我们检查了内侧额叶皮层（MfC）和腹侧海马（VH）中毒蕈碱和烟碱型乙酰胆碱受体对雄性和雌性大鼠空间工作记忆的作用。在16臂radial臂迷宫游戏中，局部注入东in碱（SCOP）和美卡敏（MEC）（10、20、50 µg /侧）可拮抗每个大脑区域中的这些受体。将SCOP注入VH导致雌性大鼠记忆力显着增加，但对雄性大鼠无显着影响，而将MEC注入VH则对两性均无影响。在MfC中同时注入SCOP（50 µg /侧）和MEC（20 µg /侧）会导致两性的工作记忆障碍。这些结果表明，VH中的毒蕈碱型乙酰胆碱受体对女性的空间记忆损害有不同的脆弱性。腹侧海马毒蕈碱型乙酰胆碱受体可能在空间记忆中的男女差异中起关键作用。

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