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A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles

机译：一夫一妻制的长期应激范例在一夫一妻制田鼠中造成社会纽带的持久损害

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Traumatic events such as natural disasters, violent crimes, tragic accidents, and war, can have devastating impacts on social relationships, including marital partnerships. We developed a single prolonged stress (SPS) paradigm, which consisted of restraint, forced swimming, and ether anesthesia, to establish an animal model relevant to post-traumatic stress disorder. We applied a SPS paradigm to a monogamous rodent, the prairie vole (Microtus ochrogaster) in order to determine whether a traumatic event affects the establishment of pair bonds. We did not detect effects of the SPS treatment on anhedonic or anxiety-like behavior. Sham-treated male voles huddled with their partner females, following a 6 day cohabitation, for a longer duration than with a novel female, indicative of a pair bond. In contrast, SPS-treated voles indiscriminately huddled with the novel and partner females. Interestingly, the impairment of pair bonding was rescued by oral administration of paroxetine, a selective serotonin reuptake inhibitor (SSRI), after the SPS treatment. Immunohistochemical analyses revealed that oxytocin immunoreactivity (IR) was significantly decreased in the supraoptic nucleus (SON), but not in the paraventricular nucleus (PVN), 7 days after SPS treatment, and recovered 14 days after SPS treatment. After the presentation of a partner female, oxytocin neurons labeled with Fos IR was significantly increased in SPS-treated voles compared with sham-treated voles regardless of paroxetine administration.Our results suggest that traumatic events disturb the formation of pair bond possibly through an interaction with the serotonergic system, and that SSRIs are candidates for the treatment of social problems caused by traumatic events. Further, a vole SPS model may be useful for understanding mechanisms underlying the impairment of social bonding by traumatic events.
机译：自然灾害，暴力犯罪，悲剧性事故和战争等创伤性事件可能对包括婚姻伴侣关系在内的社会关系产生毁灭性影响。我们开发了一种由约束，强迫游泳和以太麻醉组成的单一长时间应激（SPS）范例，以建立与创伤后应激障碍相关的动物模型。我们将SPS范例应用于一夫一妻制的啮齿动物大草原田鼠（Microtus ochrogaster），以确定创伤事件是否影响对键的建立。我们没有发现SPS治疗对快感或焦虑症行为的影响。经过6天的同居生活，经过假手术处理的雄性田鼠与雌性伴侣缩在一起的时间要比新雌性雌鼠缩的时间长，这表明配对。相反，经SPS处理的田鼠与小说和伴侣雌性杂乱无章地缩在一起。有趣的是，在SPS治疗后，通过口服帕罗西汀（一种选择性的5-羟色胺再摄取抑制剂（SSRI））可以挽救双键的损伤。免疫组织化学分析显示，SPS治疗后7天，在视上核（SON）中催产素的免疫反应性（IR）显着降低，而在室旁核中（PVN）的催产素免疫反应性（IR）明显降低，SPS治疗后14天恢复。与伴侣治疗的田鼠相比，与假治疗的田鼠相比，在伴侣女性出现后，用Fos IR标记的催产素神经元显着增加，而无论帕罗西汀如何给药。血清素能系统，SSRIs是治疗创伤事件引起的社会问题的候选药物。此外，田鼠SPS模型可能有助于理解潜在的创伤事件导致社会联系受损的机制。

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