• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats
【2h】

Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats

机译：在妊娠第12天产前急性暴露于乙醇会引起Sprague Dawley大鼠社交行为和焦虑样行为的相反缺陷

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Our previous research has shown that in Long Evans rats acute prenatal exposure to a high dose of ethanol on gestational day (G) 12 produces social deficits in male offspring and elicits substantial decreases in social preference relative to controls, in late adolescents and adults regardless of sex. In order to generalize the observed detrimental effects of ethanol exposure on G12, pregnant female Sprague Dawley rats were exposed to ethanol or saline and their offspring were assessed in a modified social interaction (SI) test as early adolescents, late adolescents, or young adults. Anxiety-like behavior was also assessed in adults using the elevated plus maze (EPM) or the light/dark box (LDB) test. Age- and sex-dependent social alterations were evident in ethanol-exposed animals. Ethanol-exposed males showed deficits in social investigation at all ages and age-dependent alterations in social preference. Play fighting was not affected in males. In contrast, ethanol-exposed early adolescent females showed no changes in social interactions, whereas older females demonstrated social deficits and social indifference. In adulthood, anxiety-like behavior was decreased in males and females prenatally exposed to ethanol in the EPM, but not the LDB. These findings suggest that social alterations associated with acute exposure to ethanol on G12 are not strain-specific, although they are more pronounced in Long Evans males and Sprague Dawley females. Furthermore, given that anxiety-like behaviors were attenuated in a test-specific manner, this study indicates that early ethanol exposure can have differential effects on different forms of anxiety.
机译：我们以前的研究表明，在长Evans大鼠中，妊娠前（G）12急性产前暴露于高剂量的乙醇会导致雄性后代的社交赤字，并且相对于对照组，无论是青少年后期还是成人，社交偏好都会大大降低。性别。为了概括观察到的乙醇暴露对G12的有害影响，将怀孕的雌性Sprague Dawley大鼠暴露于乙醇或盐水中，并以改良的社交互动（SI）测试评估其后代，分别为青春期早期，青春期晚期或年轻人。还使用高架迷宫（EPM）或明/暗盒（LDB）测试评估了成年人的焦虑样行为。在暴露于乙醇的动物中，年龄和性别依赖性的社会改变是明显的。暴露于乙醇的男性在所有年龄段的社会调查中都表现出不足，并且年龄依赖于社会偏好的改变。男性不影响打比赛。相比之下，暴露于乙醇的青春期早期女性在社交互动方面没有变化，而老年女性则表现出社交缺陷和社交冷漠。在成年期，在EPM中产前暴露于乙醇的雄性和雌性的焦虑样行为有所减少，但在LDB中却没有。这些发现表明，尽管在Long Evans男性和Sprague Dawley女性中更明显，但与G12急性暴露于乙醇相关的社会变化并不是菌株特异性的。此外，鉴于以测试特定的方式减轻了类似焦虑的行为，这项研究表明，早期乙醇暴露可以对不同形式的焦虑产生不同的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号