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首页> 美国卫生研究院文献>other >Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl
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Growing Teratoma Syndrome Secondary to Ovarian Giant Immature Teratoma in an Adolescent Girl

机译：继发于青春期少女的卵巢巨大未成熟畸胎瘤继发性畸胎瘤综合征

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Growing teratoma syndrome (GTS) is a rare clinical entity first described by Logothetis et al in 1982. Although it is unusual for GTS to be located in the ovary, this report is of a case of an adolescent girl who underwent a complete surgical resection of the mass. Histopathology confirmed only an immature teratoma had originated from the ovary and so she received adjuvant chemotherapy with blemycin, etopside, and cisplatin over 4 cycles. Results from an abdominal enhanced CT (computed tomography) 9 years later revealed a giant mass had compressed adjacent tissues and organs. Laparotomy was performed and a postoperative histopathology showed the presence of a mature teratoma, and so the diagnosis of ovarian GTS was made. One hundred one cases of ovarian GTS from English literature published between 1977 and 2015 were collected and respectively analyzed in large samples for the first time.The median age of diagnosis with primary immature teratoma was 22 years (range 4–48 years, n = 56). GTS originating from the right ovary accounted for 57% (27/47, n = 47) whereas the left contained 43% (20/47, n = 47). Median primary tumor size was 18.7 cm (range 6–45 cm, n = 28) and median subsequent tumor size was 8.6 cm (range 1–25 cm, n = 25). From the primary treatment to the diagnosis of ovarian GTS, median tumor growth speed was 0.94 cm/month (range 0.3–4.3 cm/month, n = 21). Median time interval was 26.6 months (range 1–264 months, n = 41). According to these findings, 5 patients did have a pregnancy during the time interval between primary disease and GTS, making our patient the first case of having a pregnancy following the diagnosis of ovarian GTS. Because of its high recurrence and insensitiveness to chemotherapy, complete surgical resection is the preferred treatment and fertility-sparing surgery should be considered for women of child-bearing age.Anyhow GTS of the ovary has an excellent prognosis. Patients with GTS had no evidence of recurrence or were found to be disease free during a 40.3-month (range 1–216 months, n = 48) median follow-up. Moreover, regular follow-ups with imaging and serum tumor markers are important and must not be neglected.
机译：日益增长的畸胎瘤综合征（GTS）是由Logothetis等人于1982年首次描述的一种罕见的临床实体。尽管GTS位于卵巢中是很罕见的，但本报告是一例青春期女孩接受了完整的手术切除质量。组织病理学证实只有不成熟的畸胎瘤起源于卵巢，因此她在4个周期内接受了含有博来霉素，依托泊苷和顺铂的辅助化疗。 9年后腹部增强CT（计算机断层扫描）结果显示，巨大肿物压迫了邻近的组织和器官。进行了剖腹手术，术后组织病理学显示存在成熟的畸胎瘤，因此对卵巢GTS进行了诊断。首次收集并分析了1977年至2015年间英语文献中的101例卵巢GTS病例，并分别对其进行了大样本分析。原发性未畸胎瘤的诊断中位年龄为22岁（范围4–48岁，n = 56） ）。源自右卵巢的GTS占57％（27/47，n = 47），而左侧则占43％（20/47，n = 47）。中位原发肿瘤大小为18.7厘米（6-45厘米，n = 28），中位后续肿瘤大小为8.6厘米（1-25厘米，n = 25）。从初级治疗到卵巢GTS的诊断，中位肿瘤生长速度为0.94 cm /月（范围0.3-4.3 cm /月，n = 21）。中位时间间隔为26.6个月（范围1–264个月，n = 41）。根据这些发现，有5例患者在原发疾病和GTS之间的时间间隔内确实怀孕，这使我们的患者成为卵巢GTS诊断后第一个怀孕的病例。由于其高复发性和对化学疗法不敏感，因此完全手术切除是首选治疗方法，对于育龄妇女应考虑保留生育能力。无论如何，卵巢GTS的预后良好。 GTS患者在40.3个月（范围1–216个月，n = 48）中位随访期间无复发迹象或无病。此外，定期随访的影像学检查和血清肿瘤标志物也很重要，不能忽视。

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