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首页> 美国卫生研究院文献>other >Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population: A Retrospective Study
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Risk Factors Predictive of Recurrence and Progression for Patients Who Suffered Initial Recurrence After Transurethral Resection of Stage pT1 Bladder Tumor in Chinese Population: A Retrospective Study

机译：中国人群pT1期膀胱肿瘤经尿道电切术后复发复发的危险因素预测

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Bladder cancer is one of the most common malignancies worldwide and the stage pT1nonmuscle invasive bladder cancer (NMIBC) has a high probability of recurrence after initial diagnosis and treatment. However, risk factors predictive of repeated recurrence and progression of pT1 bladder tumors after primary relapse have not been uncovered. Thus, we conducted the retrospective study.A total of 418 patients who suffered initial recurrence after transurethral resection (TUR) of pT1 bladder tumor were selected for the analyses. Clinic information of the patients was retrieved from their medical records. Recurrence-free survival (RFS) and progression-free survival (PFS) were estimated using the Kaplan–Meier method. Univariate and multivariate analyses were performed using a Cox proportional hazards regression model. The probability of recurrence and progression by multivariate analyses was used as a surrogate marker to construct receiver operating curve (ROC).Results showed that variables including time to prior recurrence time, prior treatment, number of tumor, tumor size, tumor grade, and time of instillation after surgery were associated with the repeated recurrence of pT1 bladder tumor (P < 0.05). The variables including time to prior recurrence time, tumor size, tumor grade, carcinoma in situ (CIS), and time of instillation after surgery were associated with progression of pT1 bladder tumor (P < 0.05). In the present study, the multivariate model showed an area under ROC (AUC) value of 0.754 and 0.798 for tumor recurrence and progression, respectively, which was more effective in prediction than a single risk factor.In conclusion, we have identified several risk factors relevant to RFS and PFS for patients who have had a history of recurrence of pT1 bladder tumor after TUR. These predictive factors may help urologists to stratify patients into distinct risk groups of recurrence and progression, which probably contributes to the individualized treatment for patients.
机译：膀胱癌是全世界最常见的恶性肿瘤之一，在初步诊断和治疗后，pT1期非肌肉浸润性膀胱癌（NMIBC）复发的可能性很高。然而，尚未发现预测原发性复发后pT1膀胱肿瘤反复复发和进展的危险因素。因此，我们进行了回顾性研究。共选择了418例经pT1膀胱肿瘤经尿道切除术（TUR）术后复发的患者。从患者的病历中检索患者的临床信息。使用Kaplan-Meier方法估算无复发生存期（RFS）和无进展生存期（PFS）。使用Cox比例风险回归模型进行单因素和多因素分析。通过多变量分析将复发和进展的概率用作构建受体工作曲线（ROC）的替代标志物。结果表明，变量包括至先前复发时间，先前治疗，肿瘤数目，肿瘤大小，肿瘤等级和时间术后滴注次数与pT1膀胱肿瘤反复复发有关（P <0.05）。变量包括到先前复发时间，肿瘤大小，肿瘤等级，原位癌（CIS）和手术后滴注时间与pT1膀胱肿瘤的进展相关（P <0.05）。在本研究中，多变量模型显示肿瘤复发和进展的ROC（AUC）值分别为0.754和0.798，比单个危险因素更有效地进行预测。总而言之，我们确定了几个危险因素TUR后有pT1膀胱肿瘤复发史的患者与RFS和PFS相关。这些预测因素可以帮助泌尿科医师将患者分为复发和进展的不同风险组，这可能有助于患者的个性化治疗。

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