• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Short-term sleep disturbance-induced stress does not affect basal pain perception but does delay postsurgical pain recovery
【2h】

Short-term sleep disturbance-induced stress does not affect basal pain perception but does delay postsurgical pain recovery

机译：短期睡眠障碍诱发的压力不会影响基础疼痛知觉但会延迟术后疼痛的恢复

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic sleep disturbance-induced stress is known to increase basal pain sensitivity. However, most surgical patients frequently report short-term sleep disturbance/deprivation during pre- and post-operation periods and have normal pain perception pre-surgery. Whether this short-term sleep disturbance affects postsurgical pain is elusive. We here reported that pre- or post-exposure to rapid eye movement sleep disturbance (REMSD) 6 h daily for 3 consecutive days did not alter basal responses to mechanical, heat, and cold stimuli, but did delay recovery in incision-induced reductions in paw withdrawal threshold to mechanical stimulation and paw withdrawal latencies to heat and cold stimuli on the ipsilateral side of male or female rats. This short-term REMSD led to stress evidenced by an increase in swim immobility time, a decrease in sucrose consumption, and an elevation in the level of corticosterone in serum. Blocking this stress via intrathecal RU38486 or bilateral adrenalectomy abolished REMSD-caused delay in recovery of incision-induced reductions in behavioral responses to mechanical, heat, and cold stimuli. Moreover, this short-term REMSD produced significant reductions in the levels of mu opioid receptor and kappa opioid receptor, but not Kv1.2, in the ipsilateral L4/5 spinal cord and dorsal root ganglia on day 9 post-incision (but not post-sham surgery).
机译：已知慢性睡眠障碍引起的压力会增加基础疼痛的敏感性。但是，大多数外科手术患者经常在术前和术后报告短期睡眠紊乱/剥夺，并且术前疼痛觉正常。这种短期睡眠障碍是否会影响术后疼痛尚不清楚。我们在这里报道，连续6天每天连续6天暴露于快速眼动睡眠障碍（REMSD）连续6天或之后，并没有改变对机械刺激，热刺激和冷刺激的基础反应，但确实延迟了切口诱发的眼球减少的恢复。雄性或雌性大鼠同侧的机械刺激爪退缩阈值和热和冷刺激的爪退缩潜伏期。这种短期REMSD导致的压力表现为游泳不动时间的增加，蔗糖消耗的减少以及血清中皮质酮水平的升高。通过鞘内RU38486或双侧肾上腺切除术来阻断这种压力，消除了REMSD导致的切口引起的对机械，热和冷刺激的行为反应减少的恢复的延迟。此外，这种短期REMSD在切口后第9天使同侧L4 / 5脊髓和背根神经节的mu阿片受体和κ阿片受体的水平显着降低，但不降低Kv1.2。 -假手术）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号