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首页> 美国卫生研究院文献>Journal of Functional Biomaterials >Mn2+-ZnSe/ZnS@SiO2 Nanoparticles for Turn-on Luminescence Thiol Detection
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Mn2+-ZnSe/ZnS@SiO2 Nanoparticles for Turn-on Luminescence Thiol Detection

机译：Mn2 + -ZnSe / ZnS @ SiO2纳米粒子用于开启发光硫醇检测

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Biological thiols are antioxidants essential for the prevention of disease. For example, low levels of the tripeptide glutathione are associated with heart disease, cancer, and dementia. Mn2+-doped wide bandgap semiconductor nanocrystals exhibit luminescence and magnetic properties that make them attractive for bimodal imaging. We found that these nanocrystals and silica-encapsulated nanoparticle derivatives exhibit enhanced luminescence in the presence of thiols in both organic solvent and aqueous solution. The key to using these nanocrystals as sensors is control over their surfaces. The addition of a ZnS barrier layer or shell produces more stable nanocrystals that are isolated from their surroundings, and luminescence enhancement is only observed with thinner, intermediate shells. Tunability is demonstrated with dodecanethiol and sensitivities decrease with thin, medium, and thick shells. Turn-on nanoprobe luminescence is also generated by several biological thiols, including glutathione, N-acetylcysteine, cysteine, and dithiothreitol. Nanoparticles prepared with different ZnS shell thicknesses demonstrated varying sensitivity to glutathione, which allows for the tuning of particle sensitivity without optimization. The small photoluminescence response to control amino acids and salts indicates selectivity for thiols. Preliminary magnetic measurements highlight the challenge of optimizing sensors for different imaging modalities. In this work, we assess the prospects of using these nanoparticles as luminescent turn-on thiol sensors and for MRI.
机译：生物硫醇是预防疾病必不可少的抗氧化剂。例如，低水平的三肽谷胱甘肽与心脏病，癌症和痴呆症有关。 Mn 2 + 掺杂的宽带隙半导体纳米晶体具有发光和磁性，因此对双峰成像具有吸引力。我们发现这些纳米晶体和二氧化硅包裹的纳米颗粒衍生物在有机溶剂和水溶液中都存在硫醇的情况下显示出增强的发光。使用这些纳米晶体作为传感器的关键是控制其表面。 ZnS阻挡层或外壳的添加会产生更稳定的纳米晶体，该纳米晶体与其周围的环境隔离开来，并且只有在较薄的中间外壳中才能观察到发光增强。十二烷硫醇显示出可调性，而薄，中，厚壳的灵敏度降低。几种生物硫醇（包括谷胱甘肽，N-乙酰基半胱氨酸，半胱氨酸和二硫苏糖醇）也可产生开启的纳米探针发光。用不同的ZnS壳厚度制备的纳米颗粒表现出对谷胱甘肽的不同敏感性，这使得无需优化即可调整颗粒的敏感性。对对照氨基酸和盐的小的光致发光反应表明对硫醇的选择性。初步的磁测量结果突出显示了针对不同成像方式优化传感器的挑战。在这项工作中，我们评估了将这些纳米颗粒用作发光开启硫醇传感器和MRI的前景。

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