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Quantitative Analysis of Vascular Heterogeneity in Breast Lesions Using Contrast-Enhanced 3-D Harmonic and Subharmonic Ultrasound Imaging

机译：使用对比增强的3D谐波和亚谐波超声成像定量分析乳腺癌病变中的血管异质性

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Ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced 3-D harmonic (HI) and subharmonic (SHI) ultrasound imaging was investigated in a clinical population. Patients (n = 134) identified with breast lesions on mammography were scanned using power Doppler imaging, contrast-enhanced 3-D HI, and 3-D SHI on a modified Logiq 9 scanner (GE Healthcare). A region of interest corresponding to ultrasound contrast agent flow was identified in 4D View (GE Medical Systems) and mapped to raw slice data to generate a map of time-intensity curves for the lesion volume. Time points corresponding to baseline, peak intensity, and washout of ultrasound contrast agent were identified and used to generate and compare vascular heterogeneity plots for malignant and benign lesions. Vascularity was observed with power Doppler imaging in 84 lesions (63 benign and 21 malignant). The 3-D HI showed flow in 8 lesions (5 benign and 3 malignant), whereas 3-D SHI visualized flow in 68 lesions (49 benign and 19 malignant). Analysis of vascular heterogeneity in the 3-D SHI volumes found benign lesions having a significant difference in vascularity between central and peripheral sections (1.71 ± 0.96 vs. 1.13 ± 0.79 dB, p < 0.001, respectively), whereas malignant lesions showed no difference (1.66 ± 1.39 vs. 1.24 ± 1.14 dB, p = 0.24), indicative of more vascular coverage. These preliminary results suggest quantitative evaluation of vascular heterogeneity in breast lesions using contrast-enhanced 3-D SHI is feasible and able to detect variations in vascularity between central and peripheral sections for benign and malignant lesions.
机译：在临床人群中，研究了使用造影剂增强的3D谐波（HI）和次谐波（SHI）超声成像来可视化乳腺病变血管和量化血管异质性的能力。在改良的Logiq 9扫描仪（GE Healthcare）上，使用功率多普勒成像，增强对比的3-D HI和3-D SHI对在乳腺X线照片上发现乳腺病变的患者（n = 134）进行扫描。在4D视图（GE Medical Systems）中识别了与超声造影剂流相对应的感兴趣区域，并将其映射到原始切片数据以生成病变体积的时间强度曲线图。确定对应于基线，峰值强度和超声造影剂洗脱的时间点，并将其用于生成和比较恶性和良性病变的血管异质性图。功率多普勒成像在84个病变（63例良性和21例恶性）中观察到血管。 3-D HI显示有8个病变（5个良性和3个恶性）中的血流，而3-D SHI显示了68个病变（49个良性和19个恶性）中的血流。对3-D SHI体积中的血管异质性进行分析后发现，良性病变在中央和周围区域之间具有明显的血管差异（分别为1.71±0.96与1.13±0.79 dB，p <0.001），而恶性病变则没有差异（ 1.66±1.39 dB与1.24±1.14 dB，p = 0.24），表明有更多的血管覆盖。这些初步结果表明，使用对比增强的3-D SHI对乳腺病变中的血管异质性进行定量评估是可行的，并且能够检测出良性和恶性病变的中央和周边部分之间的血管性变化。

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