• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity metabolism and the central nervous system
【2h】

Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity metabolism and the central nervous system

机译：非传统细胞因子：儿茶酚胺和脂肪因子如何影响巨噬细胞的免疫代谢和中枢神经系统

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Catecholamines and adipokines function as hormones; catecholamines as neurotransmitters in the sympathetic nervous system, and adipokines as mediators of metabolic processes. It has become increasingly clear, however, that both also function as immunomodulators of innate and adaptive immune cells, including macrophages. Macrophages can respond to, as well as produce their own catecholamines. Dopamine, noradrenaline, and adrenaline are the most abundant catecholamines in the body, and can induce both pro-inflammatory and anti-inflammatory immune responses in macrophages, as well as non-immune processes such as thermogenesis. Though they are responsive to adipokines, particularly lipoproteins, leptin, and adiponectin, macrophages generally do synthesize their own adipokines, with the exception being resistin-like molecules. Adipokines contribute to adverse metabolic and immune response by stimulating lipid accumulation, foam cell formation and pro-inflammatory cytokine production in macrophages. Adipokines can also promote balance or resolution during metabolic and immune processes by promoting reverse lipid transport and expression of Th2 cytokines. This review will explore the mechanisms by which catecholamines and adipokines influence macrophage function in neural pathways, immunity and metabolism.
机译：儿茶酚胺和脂肪因子起激素的作用；儿茶酚胺是交感神经系统中的神经递质，脂肪因子是代谢过程的介质。然而，越来越清楚的是，它们都还可以作为先天性和适应性免疫细胞（包括巨噬细胞）的免疫调节剂。巨噬细胞可以响应并产生自己的儿茶酚胺。多巴胺，去甲肾上腺素和肾上腺素是体内最丰富的儿茶酚胺，可在巨噬细胞中诱导促炎性和抗炎性免疫反应，以及非免疫过程，例如生热。尽管它们对脂肪因子，特别是脂蛋白，瘦蛋白和脂联素有反应，但巨噬细胞通常确实合成自己的脂肪因子，但抵抗素样分子除外。脂肪因子通过刺激巨噬细胞中的脂质蓄积，泡沫细胞形成和促炎性细胞因子生成，从而导致不良的代谢和免疫反应。脂肪因子还可以通过促进脂质逆向转运和Th2细胞因子的表达来促进代谢和免疫过程中的平衡或分解。这篇综述将探讨儿茶酚胺和脂肪因子在神经通路，免疫和代谢中影响巨噬细胞功能的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号