首页> 美国卫生研究院文献>other >Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7- aza-narciclasine and its N-oxide

【2h】

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7- aza-narciclasine and its N-oxide

机译：水仙子碱非天然衍生物7-氮杂-水仙子碱及其N-氧化物的合成及生物学评价

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Several unnatural derivatives of narciclasine were prepared in which the C-7 carbon was replaced with nitrogen. The 7-aza derivative and its N-oxide were prepared by the coupling of iodopicolinic acid with a conduramine unit derived chemoenzymatically from bromobenzene. Intramolecular Heck reaction was used to construct the carbostyryl ring system. The compounds were submitted to biological screening against cancer cell lines. Full experimental and spectra data are provided for all new compounds.

机译：制备了几种非天然的水杨酸衍生物，其中的C-7碳被氮取代。 7-氮杂衍生物及其N-氧化物是通过碘代吡啶甲酸与化学上衍生自溴苯的conduramine单元偶联而制得的。分子内Heck反应用于构建羧甲基苯乙烯环系统。将该化合物进行针对癌细胞系的生物筛选。提供了所有新化合物的完整实验数据和光谱数据。

著录项

期刊名称 other
作者
Sergey Vshyvenko; Mary Rose Reisenauer; Snezna Rogelj; Tomas Hudlicky;
展开▼
作者单位

展开▼
年(卷),期 -1(24),17
年度 -1
页码 4236–4238
总页数 12
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide [J] . VshyvenkoS., ReisenauerM.R., RogeljS., Bioorganic and Medicinal Chemistry Letters . 2014,第17期

机译：七环素非天然衍生物7-氮杂-正二十烷及其氮氧化物的合成及生物学评价
2. Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies [J] . Alejandra Gerpe, Gabriela Aguirre, Lucia Boiani, Bioorganic and medicinal chemistry . 2006,第10期

机译：吲唑N-氧化物衍生物作为抗原生动物剂：合成，生物学评估和作用机理
3. Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies [J] . Alejandra Gerpe, Gabriela Aguirre, Lucia Boiani, Bioorganic and Medicinal Chemistry . 2006,第10期

机译：吲唑N-氧化物衍生物作为抗原生动物剂：合成，生物学评估和作用机理
4. DESIGN,SYNTHESIS AND BIOLOGICAL EVALUATION OF 3-PHENYLISOXAZOLO5,4-DPYRIMIDINE DERIVATIVES AS ANTICANCER AGENTS [C] . Nikhil Gaikwad, Y.V.Madhavi Conference on Drug Design and Discovery Technologies . 2020

机译：3-苯基异恶唑的设计，合成和生物学评价5,4-D嘧啶衍生物作为抗癌剂
5. I. Total synthesis and biological evaluation of reblastatin, autolytimycin and related structural derivatives. II. Synthesis and biological evaluation of stereochemical analogs of bistramide A [D] . Wrona, Iwona Ewa 2009

机译：I.角质素，自身霉素和相关结构衍生物的全合成和生物学评估。二。双链酰胺A的立体化学类似物的合成和生物学评价
6. Synthesis and Preliminary Evaluation of N-Oxide Derivatives for the Prevention of Atherothrombotic Events [O] . Leandro Augusto Rosseto, Maria Elisa Lopes Pires, Aylime Castanho Bolognesi Melchior, 2015

机译：N-氧化物衍生物的合成及其对预防血栓栓塞性事件的初步评估
7. Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7-aza-nornarciclasine and its N-oxide [O] . Sergey Vshyvenko, Mary Rose Reisenauer, Snezna Rogelj, 2014

机译：Narciclasine的非自然衍生物的合成与生物学评价：7-AZA-Nornarclasine及其N氧化物

Synthesis and biological evaluation of unnatural derivatives of narciclasine: 7- aza-narciclasine and its N-oxide

摘要

著录项

相似文献

相关主题

期刊订阅