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Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development

机译：下一代DNA测序显示室内灰尘中真菌多样性低与儿童哮喘的发展有关

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Dampness and visible mold in homes are associated with asthma development, but causal mechanisms remain unclear. The goal of this research was to explore associations among measured dampness, fungal exposure, and childhood asthma development without the bias of culture-based microbial analysis. In the low-income, Latino CHAMACOS birth cohort, house dust was collected at age 12 months, and asthma status was determined at age 7 years. The current analysis included 13 asthma cases and 28 controls. Next-generation DNA sequencing methods quantified fungal taxa and diversity. Lower fungal diversity (number of fungal operational taxonomic units) was significantly associated with increased risk of asthma development: unadjusted odds ratio (OR) 4.80 (95% confidence interval (CI) 1.04–22.1). Control for potential confounders strengthened this relationship. Decreased diversity within the genus Cryptococcus was significantly associated with increased asthma risk (OR 21.0, 95% CI 2.16–204). No fungal taxon (species, genus, class) was significantly positively associated with asthma development, and one was significantly negatively associated. Elevated moisture was associated with increased fungal diversity, and moisture/mold indicators were associated with four fungal taxa. Next-generation DNA sequencing provided comprehensive estimates of fungal identity and diversity, demonstrating significant associations between low fungal diversity and childhood asthma development in this community.
机译：家庭中的潮湿和可见霉菌与哮喘的发展有关，但其致病机制仍不清楚。这项研究的目的是在没有基于培养物的微生物分析偏见的情况下，探索测得的湿度，真菌暴露和儿童哮喘的发展之间的关系。在低收入拉丁裔CHAMACOS出生队列中，在12个月大时收集房屋灰尘，并在7岁时确定哮喘状态。目前的分析包括13例哮喘病例和28例对照。下一代DNA测序方法可量化真菌分类和多样性。较低的真菌多样性（真菌操作分类单位的数量）与哮喘发生风险增加显着相关：未调整的优势比（OR）为4.80（95％置信区间（CI）为1.04-22.1）。对潜在混杂因素的控制加强了这种关系。隐球菌属内多样性的降低与哮喘风险增加显着相关（OR 21.0，95％CI 2.16–204）。没有真菌分类群（物种，属，类）与哮喘的发展呈显着正相关，而与真菌的形成呈显着负相关。水分升高与真菌多样性增加有关，水分/霉菌指示物与四种真菌类群有关。下一代DNA测序提供了真菌身份和多样性的全面估计，表明该社区低真菌多样性与儿童哮喘的发展之间存在显着关联。

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