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首页> 美国卫生研究院文献>other >Postnatal Development of the Hippocampus in the Rhesus Macaque (Macaca mulatta): A Longitudinal Magnetic Resonance Imaging Study
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Postnatal Development of the Hippocampus in the Rhesus Macaque (Macaca mulatta): A Longitudinal Magnetic Resonance Imaging Study

机译：猕猴（猕猴）海马的产后发育：纵向磁共振成像研究。

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摘要

Nonhuman primates are widely used models to investigate the neural substrates of human behavior, including the development of higher cognitive and affective function. Due to their neuroanatomical and behavioral homologies with humans, the rhesus macaque monkey (Macaca mulatta) provides an excellent animal model in which to characterize the maturation of brain structures from birth through adulthood and into senescence. To evaluate hippocampal development in rhesus macaques, structural magnetic resonance imaging scans were obtained longitudinally at 9 time points between 1 week and 260 weeks (5 years) of age on 24 rhesus macaque monkeys (12 male, 12 female). In our sample, the hippocampus reaches 50% of its adult volume by 13 weeks of age and reaches an adult volume by 52 weeks in both males and females. The hippocampus appears to be slightly larger at 3 years than at 5 years of age. Male rhesus macaques have larger hippocampi than females from 8 weeks onward by approximately 5%. Interestingly, there was increased variability in hemispheric asymmetry for hippocampus volumes at younger ages than at later ages. These data provide a comprehensive evaluation of the longitudinal development of male and female rhesus macaque hippocampus across development from 1 week to 5 years of age.
机译：非人类灵长类动物是广泛用于研究人类行为的神经基础的模型，包括更高的认知和情感功能的发展。由于其与人的神经解剖学和行为同源性，恒河猴（Macaca mulatta）提供了一个出色的动物模型，可用来描述从出生到成年直至衰老的大脑结构的成熟。为了评估猕猴的海马发育，在24周恒河猴（12只雄性，12只雌性）上，在1周至260周（5岁）的9个时间点纵向获得了结构磁共振成像扫描。在我们的样本中，海马在13周龄时达到其成年体积的50％，在雄性和雌性中至52周时都达到成年体积。 3岁时的海马似乎比5岁时的海马略大。从8周开始，雄性猕猴的海马体比雌性猕猴的大约5％。有趣的是，年轻年龄的海马体的半球不对称性的变异性较晚年龄有所增加。这些数据全面评估了从1周到5岁的雄性和雌性猕猴海马的纵向发育。

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