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首页> 外文期刊>Brain research. Brain research protocols >Anesthetic protocol: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application.
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Anesthetic protocol: propofol use in Rhesus macaques (Macaca mulatta) during magnetic resonance imaging with stereotactic head frame application.

机译：麻醉方案：在立体定向头架磁共振成像中恒河猴（猕猴）中使用异丙酚。

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摘要

Magnetic resonance image (MRI) guidance is often necessary for accurate targeting for stereotactic intracranial surgery in animals used for experimental research studies. The magnetic field created by the MR imaging equipment, logistics of the use of stereotactic head frame in confined space and the need to limit movement of the subject during the imaging creates unique challenges. We demonstrate in this study the usefulness of intravenous propofol to anesthetize adult Rhesus monkeys to obtain high resolution 3D MR images immediately followed by conversion to inhalation anesthesia and stereotactic intracranial surgery with the head frame 'in situ.' There was minimal morbidity with achieving a high degree of precision for the stereotactic targeting.
机译：为了对用于实验研究的动物进行立体定向颅内手术进行精确定位，通常需要磁共振成像（MRI）指导。 MR成像设备产生的磁场，有限空间中立体定向头架的使用以及在成像过程中限制对象移动的需求带来了独特的挑战。在这项研究中，我们证明了静脉使用异丙酚麻醉成年恒河猴以获得高分辨率的3D MR图像，然后立即转换为吸入麻醉和头部架在原位的立体定向颅内手术的有效性。立体定向靶向的发病率极低，并且具有很高的精确度。

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