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Study Design Considerations for Evaluating Efficacy of Systemic Pre-Exposure Prophylaxis Interventions

机译：评价系统性暴露前预防干预措施疗效的研究设计注意事项

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BackgroundThe development of interventions for systemic Pre-Exposure Prophylaxis (PrEP) faces several significant challenges following the US Food and Drug Administration’s (FDA) approval of Emtricitabine/Tenofovir (FTC/TDF) for HIV prevention. This development is particularly complex because of inconsistency of efficacy results of FTC/TDF PrEP trials for HIV prevention.

机译：背景技术在美国食品药品监督管理局（FDA）批准恩曲他滨/替诺福韦（FTC / TDF）预防HIV感染后，系统性暴露前预防（PrEP）干预措施的发展面临若干重大挑战。由于FTC / TDF PrEP试验在预防HIV中的功效结果不一致，因此这一进展特别复杂。

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期刊名称 other
作者
Deborah Donnell; James P. Hughes; Lei Wang; Ying Q. Chen; Thomas R. Fleming;
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作者单位

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年(卷),期 -1(63),0 2
年度 -1
页码 S130–S134
总页数 11
原文格式 PDF
正文语种
中图分类
关键词
Pre-exposure Prophylaxis Non-inferiority efficacy phase 3 clinical trials adherence;

机译：暴露前预防;非自卑;疗效;3期;临床试验;依从性;

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专利

1. Study design considerations for evaluating efficacy of systemic preexposure prophylaxis interventions. [J] . Deborah Donnell, James P Hughes, Lei Wang, JAIDS: Journal of acquired immune deficiency syndromes . 2013,第Suppla2期

机译：研究设计注意事项，用于评估全身暴露前预防干预措施的功效。
2. Protocol for an HIV Pre-exposure Prophylaxis (PrEP) Population Level Intervention Study in Victoria Australia: The PrEPX Study [J] . Kathleen E. Ryan, Anne Mak, Mark Stoove, Frontiers in Public Health . 2018,第2期

机译：澳大利亚维多利亚州的HIV暴露前预防（PrEP）人群水平干预研究的方案：PrEPX研究
3. “I think everybody should take it if they’re doing drugs, doing heroin, or having sex for money”: a qualitative study exploring perceptions of pre-exposure prophylaxis among female participants in an opioid intervention court program [J] . Sarahmona M. Przybyla, Catherine Cerulli, Jacob Bleasdale, Substance Abuse Treatment, Prevention, and Policy . 2020,第1期

机译：“我认为每个人都应该服用它，如果他们正在做毒品，做海洛因，或对钱进行性行为”：一个定性研究探讨阿片类药物干预法院方案中女性参与者在女性参与者中的预防预防的看法
4. Arctic intervention vessels – design considerations and verification studies [C] . T. E. Berg, B. O. Berge, H. Borgen Arctic Technology Conference . 2012

机译：北极干预船 - 设计考虑和验证研究
5. The impact of supervisory interventions on self-efficacy and anxiety of counselors--an evaluation of the single case research design. [D] . Kopala, Mary. 1987

机译：监督干预对辅导员自我效能感和焦虑的影响-对单例研究设计的评估。
6. Protocol for an HIV Pre-exposure Prophylaxis (PrEP) Population Level Intervention Study in Victoria Australia: The PrEPX Study [O] . Kathleen E. Ryan, Anne Mak, Mark Stoove, 2018

机译：澳大利亚维多利亚州的HIV暴露前预防（PrEP）人群水平干预研究的方案：PrEPX研究
7. Nanoencapsulation introduces long-acting phenomenon to tenofovir alafenamide and emtricitabine drug combination: A comparative pre-exposure prophylaxis efficacy study against HIV-1 vaginal transmission [O] . Subhra Mandal, Guobin Kang, Pavan Kumar Prathipati, 2019

机译：Nanoencaplation将长效现象引入Tenofovir Alafenainide和Emtricistabine药物组合：对HIV-1阴道透射的比较预曝光预防疗效研究
8. Considerations for the Design of a Systemic Review of Interventions for Preventing Clinical Alzheimer’s-Type Dementia, Mild Cognitive Impairment, and Age-Related Cognitive Decline. Letter Report. [R] . 2015

机译：设计预防临床阿尔茨海默氏型痴呆，轻度认知障碍和年龄相关认知衰退的干预系统评价的考虑因素。信报告。

Study Design Considerations for Evaluating Efficacy of Systemic Pre-Exposure Prophylaxis Interventions

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