• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of Exercise Nutrition Biochemistry >Neuroprotective effects of treadmill exercise on BDNF and PI3-K/Akt signaling pathway in the cortex of transgenic mice model of Alzheimer’s disease
【2h】

Neuroprotective effects of treadmill exercise on BDNF and PI3-K/Akt signaling pathway in the cortex of transgenic mice model of Alzheimer’s disease

机译：跑步机运动对阿尔茨海默病转基因小鼠皮层中BDNF和PI3-K / Akt信号通路的神经保护作用

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

(AD). Although physical exercise and AD have received attention in the scientific literature, the mechanism through which treadmill exercise may impact the brain insulin signaling of AD has not been elucidated. This study aimed to evaluate the neuroprotective effects of treadmill exercise on apoptotic factors (Bcl-2/Bax ratio, caspase-3), HSP70, COX-2, BDNF and PI3-K/Akt signaling pathway in the cortex of NSE/hPS2m transgenic mice model of AD. Treadmill exercise ameliorated cognitive function in water maze test and significantly increased the level of Bcl-2/Bax ratio and HSP-70 in Tg-exe group compared to Tg-con group; on the other hand, it significantly decreased the expression of caspase-3 and COX-2 in Tg-exe group compared to Tg-con group. In addition, treadmill exercise significantly increased the expression of BDNF and PI3K/Akt in Tg-exe group compared to Tg-con group. Consequently, treadmill exercise improves cognitive function possibly via activating neurotrophic factor, BDNF and PI3k/Akt signaling pathway, and Aβ-induced neuronal cell death in the cortex of Tg mice was markedly suppressed following treadmill exercise. These results suggest that treadmill exercise may be beneficial in preventing or treating Alzheimer’s disease.
机译：（广告）。尽管体育锻炼和AD在科学文献中受到关注，但跑步机锻炼可能影响AD的脑胰岛素信号传导的机制尚未阐明。这项研究旨在评估跑步机运动对NSE / hPS2m转基因皮层中凋亡因子（Bcl-2 / Bax比，caspase-3），HSP70，COX-2，BDNF和PI3-K / Akt信号通路的神经保护作用。 AD的小鼠模型。与Tg-con组相比，Tg-exe组的跑步机锻炼改善了水迷宫测试中的认知功能，并显着提高了Bcl-2 / Bax比和HSP-70的水平；另一方面，与Tg-con组相比，它显着降低了Tg-exe组中caspase-3和COX-2的表达。此外，与Tg-con组相比，Tg-exe组的跑步机锻炼显着增加了BDNF和PI3K / Akt的表达。因此，跑步机运动可能通过激活神经营养因子，BDNF和PI3k / Akt信号通路来改善认知功能，并且在跑步机运动后，Aβ诱导的Tg小鼠皮层神经元细胞死亡得到明显抑制。这些结果表明，跑步机锻炼可能对预防或治疗阿尔茨海默氏病有益。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号