首页> 美国卫生研究院文献>other >Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N4-Substituted Thiosemicarbazones and Their Cu(II) Complexes

【2h】

Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N4-Substituted Thiosemicarbazones and Their Cu(II) Complexes

机译：在α-杂环-N4-取代硫代半卡巴腙的系列及其铜（II）配合物的拓扑异构酶IIα抑制和抗增殖活性金属化的作用

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

The topoisomerase-IIα inhibition and antiproliferative activity of α-heterocyclic thiosemicarbazones and their corresponding copper(II) complexes have been investigated. The Cu^II(thiosemicarbazonato)Cl complexes were shown to catalytically inhibit topoisomerase-IIα at concentrations (0.3–7.2 μM) over an order of magnitude lower than their corresponding thiosemicarbazone ligands alone. The copper complexes were also shown to inhibit the proliferation of breast cancer cells expressing high levels of topoisomerase-IIα (SK-BR-3) at lower concentrations than cells expressing lower levels of the enzyme (MCF-7).

著录项

期刊名称 other
作者
Brian M. Zeglis; Vadim Divilov; Jason S. Lewis;
展开▼
作者单位

展开▼
年(卷),期 -1(54),7
年度 -1
页码 2391–2398
总页数 21
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Role of Metalation in the Topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N 4-substituted thiosemicarbazones and their Cu(II) complexes [J] . Zeglis B.M., Divilov V., Lewis J.S. Journal of Medicinal Chemistry . 2011,第7期

机译：金属化在拓扑异构酶IIα抑制和一系列α-杂环-N 4取代的硫代半氨基甲酮及其Cu（II）配合物的抗增殖活性中的作用
2. Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells [J] . Edward C. Lisic, Victoria G. Rand, Lana Ngo, Open Journal of Medicinal Chemistry . 2018,第2期

机译：铜（II）丙酰基-噻唑硫杂氨基甲酸酯复合物：晶体结构，人类拓扑异构酶IIα的抑制作用和对乳腺癌细胞的活性。
3. Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells [J] . Jennifer D. Conner, Wathsala Medawala, Madison T. Stephens, Open Journal of Inorganic Chemistry . 2016,第2期

机译：铜（II）苯甲酰基吡啶硫杂碳脲酮配合物：人拓扑异构酶IIα的抑制作用和对乳腺癌细胞的活性。
4. METAL-ORGANIC COMPLEXES OF CU (II): GROUND STATE AND EXCHANGE INTERACTIONS IN MAGNETIC SUBSYSTEM Aifetal-organic complexes ofCu(II) [C] . A. Anders, O. Kravchyna, A. Kaplienko, NATO Advanced Research Workshop on Frontiers in Spectroscopy of Emerging Materials: Recent Advances toward New Technologies . 2004

机译：Cu（II）金属 - 有机络合物：磁性子系统偶联 - 有机复合物的地态和交换相互作用（II）
5. DNA binding studies of a series of potential anti-tumor agents: Thiosemicarbazone ligands and their palladium (II) metal complexes. [D] . Patel, Keyuri. 2010

机译：一系列潜在抗肿瘤剂的DNA结合研究：硫半脲配体及其钯（II）金属配合物。
6. Synthesis and Characterization of Novel Cu(II) Pd(II) and Pt(II) Complexes with 8-Ethyl-2-hydroxytricyclo(7.3.1.027)tridecan-13-one-thiosemicarbazone: Antimicrobial and in Vitro Antiproliferative Activity [O] . Elena Pahonțu, Codruța Paraschivescu, Diana-Carolina Ilieș, 2016

机译：具有8-乙基-2-羟基三环（7.3.1.027）tidecan-13-one-thiosemicarbazone的新型Cu（II）Pd（II）和Pt（II）配合物的合成和表征：抗菌和体外抗增殖活性
7. Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIiα/i and Activity against Breast Cancer Cells [O] . Jennifer D. Conner, Wathsala Medawala, Madison T. Stephens, 2016

机译：铜（II）苯甲酰吡啶硫代吡啶哌啶哒哒哒哒哒哒哒哒哒哒哒哒哒菌属酶II抑制抑制乳腺癌细胞的活性

Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N4-Substituted Thiosemicarbazones and Their Cu(II) Complexes

摘要

著录项

相似文献

相关主题

期刊订阅