PRENATAL TCDD IN MICE INCREASES ADULT AUTOIMMUNITY

机译：小鼠的产前TCDD增加了成人自身免疫

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Two immunologically-different mouse strains, C57BL/6 and SNF1, were exposed to a mid-gestation dose of TCDD. The C57BL/6 mouse has a high-affinity aryl hydrocarbon receptor (AhR) and is sensitive to TCDD. The SNF1 mouse has a low-affinity AhR but spontaneously develops autoimmune nephritis. Autoreactive Vβ⁺CD4⁺17a and Vβ⁺CD3⁺ T cells were increased at 24-weeks-of-age in offspring of C57BL/6 mice, more so in females than males. The cytokine IFN-γ was elevated in the females, while IL-10 was elevated in males. Phenotypic changes in B-lineage cells were present in bone marrow and spleen, and circulating autoantibodies were increased after prenatal TCDD. Kidneys of males showed significant anti-IgG and anti-C3 deposition, suggesting early-stage autoimmune disease. The SNF1 offspring similarly showed increased peripheral Vβ⁺ cells in the females, increased autoantibody production in both sexes, and increased IFN-γ production in females. Male SNF1 mice had increased anti-IgG and anti-C3 deposition in kidneys. Both mouse models therefore showed clear signatures of enhanced autoimmunity after prenatal TCDD.

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期刊名称 other
作者
Steven D. Holladay; Robert M. Gogal Jr.;
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年(卷),期 -1(31),3
年度 -1
页码 312–318
总页数 15
原文格式 PDF
正文语种
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关键词
TCDD autoimmunity developmental C57BL/6 SNF1 lupus nephritis;

机译：TCDD;自身免疫;发育;C57BL / 6;SNF1;狼疮性肾炎;

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专利

1. Prenatal TCDD in mice increases adult autoimmunity. [J] . Holladay SD, Mustafa A, Gogal RM Jr Reproductive toxicology . 2011,第3期

机译：小鼠的产前TCDD可提高成年自身免疫性。
2. Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice. [J] . Cummings AM, Hedge JM, Birnbaum LS Toxicological sciences: An official journal of the Society of Toxicology . 1999,第1期

机译：产前暴露于TCDD对成年雌性大鼠和小鼠中TCDD促进子宫内膜异位病变生长的影响。
3. Prenatal maternal vaginal inflammation increases anxiety and alters HPA axis signalling in adult male mice [J] . Wang Huan-Li, Pei De-En, Yang Ri-Dong, International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience . 2019,第期

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4. Neonatal Monosodium Glutamate Administration Increases Aminooxyacetic Acid (AOA) Susceptibility Effects In Adult Mice [C] . Alfonso Efrafn Campos-Sepulveda, Maria Elena Martinez Enrfquez, Raul Rodrfguez Arellanes, Western Pharmacology Society . 2009

机译：新生儿单钠谷氨酸给药增加了成年小鼠的氨基氧乙酸（AOA）敏感性
5. Acute Post-Ischemic Seizures are Associated with Increased Mortality and Brain Damage Following Hypoxia-Ischemia in Adult Mice [D] . El-Hayek, Youssef Hanna 2011

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6. Prenatal and postnatal alcohol exposure increases vulnerability to cocaine addiction in adult mice [O] . Lídia Cantacorps, Sandra Montagud‐Romero, Miguel Ángel Luján, 2020

机译：产前和产后酒精暴露会增加成人小鼠的可卡因成瘾的脆弱性
7. Prenatal TCDD in mice increases adult autoimmunity [O] . Steven D. Holladay, Amjad Mustafa, Robert M. Gogal 2011

机译：小鼠的产前TCDD增加了成人自身免疫
8. Evaluation of 2,4-Dichlorophenoxyacetic Acid (2,4-D), 2,4,5-Trichlorophenoxyacetic Acid (2,4,5-T), and 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Toxicity in C57BL/6 Mice: Reproduction and Fertility in Treated Male Mice and Evaluation of Congenital Malformations in Their Offspring [R] . Lamb, J. C. , Moore, J. A. , Marks, T. A. 1980

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PRENATAL TCDD IN MICE INCREASES ADULT AUTOIMMUNITY

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