• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Prenatal TCDD in mice increases adult autoimmunity.
【24h】

Prenatal TCDD in mice increases adult autoimmunity.

机译：小鼠的产前TCDD可提高成年自身免疫性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two immunologically different mouse strains, C57BL/6 and SNF(1), were exposed to a mid-gestation dose of TCDD. The C57BL/6 mouse has a high-affinity aryl hydrocarbon receptor (AhR) and is sensitive to TCDD. The SNF(1) mouse has a low-affinity AhR but spontaneously develops autoimmune nephritis. Autoreactive Vbeta(+)CD4(+)17a and Vbeta(+)CD3(+) T cells were increased at 24-weeks-of-age in offspring of C57BL/6 mice, more so in females than males. The cytokine IFN-gamma was elevated in the females, while IL-10 was elevated in males. Phenotypic changes in B-lineage cells were present in bone marrow and spleen, and circulating autoantibodies were increased after prenatal TCDD. Kidneys of males showed significant anti-IgG and anti-C3 deposition, suggesting early-stage autoimmune disease. The SNF(1) offspring similarly showed increased peripheral Vbeta(+) cells in the females, increased autoantibody production in both sexes, and increased IFN-gamma production in females. Male SNF(1) mice had increased anti-IgG and anti-C3 deposition in kidneys. Both mouse models therefore showed clear signatures of enhanced autoimmunity after prenatal TCDD.
机译：将两种免疫学上不同的小鼠品系C57BL / 6和SNF（1）暴露于妊娠中期TCDD。 C57BL / 6小鼠具有高亲和力的芳烃受体（AhR），并且对TCDD敏感。 SNF（1）小鼠具有低亲和力的AhR，但会自发发展为自身免疫性肾炎。 C57BL / 6小鼠的后代在24周龄时自身反应性Vbeta（+）CD4（+）17a和Vbeta（+）CD3（+）T细胞增加，女性比男性多。女性的细胞因子IFN-γ升高，而男性的IL-10升高。产前TCDD后，骨髓和脾脏中存在B谱系细胞的表型变化，循环中的自身抗体增加。男性肾脏显示出显着的抗IgG和抗C3沉积，提示早期自身免疫性疾病。 SNF（1）的后代类似地显示出雌性的外周Vbeta（+）细胞增加，男女中自身抗体的产生增加以及雌性中IFN-γ的产生增加。雄性SNF（1）小鼠肾脏中的抗IgG和抗C3沉积增加。因此，两种小鼠模型在产前TCDD后均显示出增强的自身免疫性的清晰特征。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号