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Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-24-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-246(1H3H5H)-triones as potent radio-sensitizing agents

机译：新型取代（Z）-5 - （（N-苄基-1H-吲哚-3-基）亚甲基）咪唑烷-24-二乙酯和5-（（N-苄基-1H-吲哚-3-基）亚甲基）嘧啶-246（1H3H5H） - 标纹作为有效的无线电敏化剂

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A series of (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-dione (>9a–9m) and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione (>10a–10i) derivatives that incorporate a variety of aromatic substituents in both the indole and N-benzyl moieties have been synthesized. These analogs were evaluated for their radiosensitization activity against the HT-29 cell line. Three analogs, >10a, 10b, and >10c were identified as the most potent radiosensitizing agents.

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期刊名称 other
作者
Y. Thirupathi Reddy; Konjeti R. Sekhar; Nidhish Sasi; P. Narsimha Reddy; Michael L. Freeman; Peter A. Crooks;
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作者单位

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年(卷),期 -1(20),2
年度 -1
页码 600–602
总页数 9
原文格式 PDF
正文语种
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关键词
Aplysinopsin analogs Radiosensitizing agents Indolyl barbiturates Indolyl hydantoins;

机译：Apssinopsin类似物;放射增敏剂;吲哚基巴比妥酸盐;吲哚基乙内酰脲;

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1. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. [J] . Reddy YT, Sekhar KR, Sasi Bioorganic and Medicinal Chemistry Letters . 2010,第2期

机译：新型取代的（Z）-5-（（（N-苄基-1H-吲哚-3-基）亚甲基）咪唑烷-2,4-二酮和5-（（N-苄基-1H-吲哚-3-基）亚甲基）嘧啶-2,4,6（1H，3H，5H）-三酮类作为有效的放射增敏剂。
2. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents. [J] . Reddy YT, Sekhar KR, Sasi Bioorganic and Medicinal Chemistry Letters . 2010,第2期

机译：新型取代的（Z）-5-（（（N-苄基-1H-吲哚-3-基）亚甲基）咪唑烷-2,4-二酮和5-（（N-苄基-1H-吲哚-3-基）亚甲基）嘧啶-2,4,6（1H，3H，5H）-三酮类作为有效的放射增敏剂。
3. Synthesis and pharmacological evaluation of substituted 5-(4-(2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy)pheny l)methylene)thiazolidine-2,4-dione derivatives as potent euglycemic and hypolipidemic agents. [J] . Gupta D, Ghosh NN, Chandra R Bioorganic and Medicinal Chemistry Letters . 2005,第4期

机译：取代的5-（4-（2-（6-（6,7-二甲基-1,2,3,4-四氢-2-氧代-4-喹喔啉基）乙氧基）苯基）亚甲基）噻唑烷-2的合成及药理学评价4-二酮衍生物作为有效的降血糖药和降血脂药。
4. The Effects of the Cis- and Trans -Gnetin H Isolated from Paeonia Suffruticosa and a Synthetic Aurone, (Z)-2-((5-(Hydroxylmethyl) Furan-2-Yl) Methylene) Benzofuran-3(2H)-One on NF-kappaB and MAPK Pathways in LPS-Stimulated Macrophages. [D] . Park, Hyo S. 2017

机译：牡丹皮和合成金莲花（Z）-2-（（5-（羟甲基）呋喃-2-Yl）亚甲基）苯并呋喃-3（2H）-One的顺-和反-Gnetin H的影响LPS刺激的巨噬细胞中的NF-κB和MAPK途径。
5. Design synthesis and discovery of 5-((13-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-246(1H3H5H)-triones and related derivatives as novel inhibitors of mPGES-1 [O] . Kai Ding, Ziyuan Zhou, Shuo Zhou, -1

机译：设计合成和发现5-（（（13-二苯基-1H-吡唑-4-基）亚甲基）嘧啶-246（1H3H5H）-三酮和相关衍生物作为新型抑制剂mPGES-1
6. Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents [O] . Y. Thirupathi Reddy, Konjeti R. Sekhar, Nidhish Sasi, 2010

机译：新型取代（Z）-5 - （（N-苄基-1H-吲哚-3-基）亚甲基）咪唑烷-2,4-二乙酯和5-（（N-苄基-1H-吲哚-3-基）亚甲基）嘧啶-2,4,6（1H，3H，5H） - 标纹作为有效的无线电敏化剂
7. Investigation of nonchlorinated substitute cleaning agents for methylene chloride. [R] . Salerno, R. F., Dichiaro, J. V., Egleston, E. E., 1990

机译：非氯化二氯甲烷替代清洗剂的研究。

Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-24-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-246(1H3H5H)-triones as potent radio-sensitizing agents

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