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Associations of free fatty acids with insulin secretion and action among African-American and European-American girls and women

机译:与非洲美洲和欧洲裔女孩和妇女的胰岛素分泌和作用的游离脂肪酸协会

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摘要

Ethnic differences in insulin secretion and action between African-Americans (AA) and European-Americans (EA) may influence mobilization of free fatty acids (FFA). We tested the hypotheses that FFA concentrations would be associated with measures of insulin secretion and action before and during a glucose challenge test. Subjects were 48 pre-pubertal girls, 60 pre-menopausal women, and 46 post-menopausal women. Fasting insulin (insulin0), the acute insulin response to glucose (AIRg), the insulin sensitivity index (SI), basal and nadir FFA (FFA0, FFAnadir), and nadir time (TIMEnadir) were determined during an intravenous glucose tolerance test. Stepwise multiple linear regression (MLR) analysis was conducted to identify associations of FFA0, FFAnadir, and TIMEnadir with ethnicity, age group, insulin measures, indices of body composition from DXA, and measures of fat distribution from CT scan. In this population, insulin0 and AIRg were higher among AA vs. EA, whereas SI was lower, independent of age group. MLR analyses indicated that FFA0 was best predicted by lean tissue mass, leg fat mass, ethnicity (lower in AA), SI, and insulin0. FFAnadir was best predicted by FFA0, age group, and intra-abdominal adipose tissue. TIMEnadir was best predicted by leg fat mass, AIRg, and SI. In conclusion, indices of insulin secretion and action were associated with FFA dynamics in healthy girls and women. Lower FFA0 among AA was independent of insulin0 and Si. Whether lower FFA0 is associated with substrate oxidation or risk for obesity remains to be determined.

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