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首页> 外文期刊>BMJ Open Diabetes Research & Care >Individual free fatty acids have unique associations with inflammatory biomarkers, insulin resistance and insulin secretion in healthy and gestational diabetic pregnant women
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Individual free fatty acids have unique associations with inflammatory biomarkers, insulin resistance and insulin secretion in healthy and gestational diabetic pregnant women

机译：在健康和妊娠糖尿病孕妇中，每种游离脂肪酸与炎性生物标志物，胰岛素抵抗和胰岛素分泌有着独特的联系。

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Objective We investigated the relationships of maternal circulating individual free fatty acids (FFA) with insulin resistance, insulin secretion and inflammatory biomarkers during mid-pregnancy.Research design and methods The data were drawn from a prospective cohort of generally healthy pregnant women (n=1368, African-American 36%, Hispanic 48%, Caucasian 16%) in Camden, NJ. We quantitatively determined 11 FFAs, seven cytokine/adipokine, homeostatic model assessment of insulin resistance (HOMA-IR) and C-peptide levels from the fasting blood samples that were collected at 16 weeks of gestation. Multivariate analyses were performed along with separate analyses for each individual FFA.Results High HOMA-IR (p0.001) and C-peptide (p0.0001) levels were positively associated with a twofold to fourfold increased risk for developing gestational diabetes mellitus (GDM). Negative relationships were found with specific FFAs (molecular percentage, palmitoleic, oleic, linolenic, myristic acids) and HOMA-IR and C-peptide levels (p0.01?to p0.0001). In contrast, palmitic, stearic, arachidonic, dihomo-γ-linolenic (DGLA) and docosahexaenoic acids were positively associated with HOMA-IR and C-peptide (p0.01?to p0.0001). The individual FFAs also predicted cytokine/adipokine levels. For example, women who had elevated DGLA (highest quartile) were twice as (adjusted OR 2.06, 95%?CI 1.42 to 2.98) likely to have higher interleukin (IL)-8 (p0.0001) levels. Conversely, women with high palmitoleic, oleic, and linolenic acid levels had reduced odds (≥2-fold, p0.01?to p0.001) for having higher IL-8, IL-6 or tumor necrosis factor-alpha levels.Conclusion Our results suggest that maternal individual FFAs uniquely affect insulin resistance and secretion. The effects are either direct or indirect via modulation of the inflammatory response. Modifying the composition of FFAs may help in reducing the risk of GDM.
机译：目的研究孕中期孕妇循环中的游离游离脂肪酸（FFA）与胰岛素抵抗，胰岛素分泌和炎性生物标志物的关系。研究设计和方法数据来自一般健康孕妇的前瞻性队列（n = 1368） ，非裔美国人36％，西班牙裔48％，白种人16％）。我们从妊娠16周的空腹血样中定量确定了11种FFA，7种细胞因子/脂肪因子，胰岛素抵抗的稳态模型评估（HOMA-IR）和C肽水平。对每个个体FFA进行多变量分析和单独分析。结果高HOMA-IR（p <0.001）和C肽（p <0.0001）水平与妊娠糖尿病（GDM）发生风险增加2到4倍呈正相关）。发现与特定的FFA（分子百分比，棕榈油酸，油酸，亚麻酸，肉豆蔻酸），HOMA-IR和C肽水平呈负相关（p <0.01至p <0.0001）。相反，棕榈酸，硬脂酸，花生四烯酸，二高-γ-亚麻酸（DGLA）和二十二碳六烯酸与HOMA-IR和C肽呈正相关（p <0.01？至p <0.0001）。各个FFA还可预测细胞因子/脂肪因子水平。例如，DGLA（最高四分位数）升高的女性的白细胞介素（IL）-8水平（p <0.0001）是正常人群的两倍（校正后的OR 2.06，95％CI 1.42至2.98）。相反，高棕榈油酸，油酸和亚麻酸水平的妇女因IL-8，IL-6或肿瘤坏死因子-α水平较高而发生机率降低（≥2倍，p <0.01？至p <0.001）。我们的结果表明，孕妇个体FFA独特地影响胰岛素抵抗和分泌。通过调节炎症反应是直接或间接的。修改FFA的组成可能有助于降低GDM的风险。

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