...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical Medicine Research >Higher Fasting and Postprandial Free Fatty Acid Levels Are Associated With Higher Muscle Insulin Resistance and Lower Insulin Secretion in Young Non-Obese Women
【24h】

Higher Fasting and Postprandial Free Fatty Acid Levels Are Associated With Higher Muscle Insulin Resistance and Lower Insulin Secretion in Young Non-Obese Women

机译：较高的禁食和餐后游离脂肪酸水平与年轻的非肥胖女性的较高的肌肉胰岛素抵抗和较低的胰岛素分泌有关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: To assess the relationship of the shape of glucose concentration curve during a standardized meal test to serum free fatty acid (FFA) concentrations, insulin resistance and insulin secretion in young non-obese women. Methods: Thirty-five young women had a standardized meal for breakfast with measurement of glucose, insulin and FFA concentrations at 0 (fasting), 30, 60 and 120 min; the areas under the concentration curves were calculated (AUCg, AUCi and AUCffa, respectively). Meal-induced insulin response (MIR) was calculated as the ratio between the incremental insulin and glucose concentrations during the first 30 min of meal tests. In two women (group A), post-breakfast glucose (PBG) returned to levels below fasting plasma glucose (FPG) at 30 min; in 15 and 11 women, PBG returned to levels below FPG at 60 and 120 min (groups B and C, respectively). In the remaining seven women (group D), PBG never fell below FPG. Results: Despite no difference in fasting insulin and AUCi, fasting FFA, AUCg and AUCffa were the lowest in group A, increased linearly from group B to C and plateaued in group D, whereas MIR might be the highest in group A, decreased from group B to C and plateaued in group D. Conclusion: Young women whose PBG returned to FPG more slowly had higher muscle insulin resistance and lower MIR associated with higher fasting and postprandial FFA levels compared with young women whose PBG returned to baseline more quickly.
机译：背景：为了评估标准化膳食测试中葡萄糖浓度曲线的形状与年轻非肥胖女性的血清游离脂肪酸（FFA）浓度，胰岛素抵抗和胰岛素分泌之间的关系。方法：35名年轻妇女在早餐时吃了一顿标准餐，在0（禁食），30、60和120分钟时测量了葡萄糖，胰岛素和FFA的浓度;计算浓度曲线下的面积（分别为AUCg，AUCi和AUCffa）。进餐诱导的胰岛素反应（MIR）计算为进餐测试的前30分钟内增量胰岛素和葡萄糖浓度之间的比率。在两名妇女（A组）中，早餐后30分钟的空腹血糖（PBG）恢复至低于空腹血浆葡萄糖（FPG）的水平。在15和11位女性中，PBG在60分钟和120分钟时分别降至FPG以下（分别为B组和C组）。在其余七名妇女（D组）中，PBG从未低于FPG。结果：尽管空腹胰岛素和AUCi没有差异，但空腹FFA，AUCg和AUCffa在A组中最低，从B组到C呈线性增加，在D组达到稳定，而MIR可能在A组中最高，而从A组下降B至C，在D组中处于稳定状态。结论：与PBG较快返回基线的年轻女性相比，PBG较慢返回FPG的年轻女性具有较高的肌肉胰岛素抵抗和较低的MIR，与较高的禁食和餐后FFA水平相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号