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首页> 美国卫生研究院文献>other >Photo-crosslinked Hybrid Polymer Networks Consisting of Poly(propylene fumarate) (PPF) and Poly(caprolactone fumarate) (PCLF): Controlled Physical Properties and Regulated Bone and Nerve Cell Responses
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Photo-crosslinked Hybrid Polymer Networks Consisting of Poly(propylene fumarate) (PPF) and Poly(caprolactone fumarate) (PCLF): Controlled Physical Properties and Regulated Bone and Nerve Cell Responses

机译：聚富马酸丙二酯（PPF）和富马酸聚己内酯（PCLF）组成的光交联杂化聚合物网络：受控的物理性质以及受调节的骨和神经细胞反应

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Aiming to achieve suitable polymeric biomaterials with controlled physical properties for hard and soft tissue replacements, we have developed a series of blends consisting of two photo-crosslinkable polymers: polypropylene fumarate (PPF) and polycaprolactone fumarate (PCLF). Physical properties of both uncrosslinked and UV crosslinked PPF/PCLF blends with PPF composition ranging from 0% to 100% have been investigated extensively. It has been found that the physical properties such as thermal, rheological, and mechanical properties could be modulated efficiently by varying the PPF composition in the blends. Thermal properties including glass transition temperature (Tg) and melting temperature (Tm) have been correlated with their rheological and mechanical properties. Surface characteristics such as surface morphology, hydrophilicity and the capability of adsorbing serum protein from culture medium have also been examined for the crosslinked polymer and blend discs. For potential applications in bone and nerve tissue engineering, in vitro cell studies including cytotoxicity, cell adhesion, and proliferation on crosslinked discs with controlled physical properties have been performed using rat bone marrow stromal cells and SPL201 cells, respectively. In addition, the role of mechanical properties such as surface stiffness in modulating cell responses has been emphasized using this model blend system.
机译：为了获得具有可控物理特性的硬聚合物和软组织替代物的合适聚合物生物材料，我们开发了一系列共混物，其中包括两种可光交联的聚合物：富马酸聚丙烯酸酯（PPF）和富马酸聚己内酯（PCLF）。 PPF组成为0％至100％的未交联和UV交联的PPF / PCLF共混物的物理性能已得到广泛研究。已经发现，通过改变共混物中的PPF组成，可以有效地调节物理性质，例如热，流变和机械性质。包括玻璃化转变温度（Tg）和熔融温度（Tm）在内的热性能已与其流变和机械性能相关联。还针对交联的聚合物和共混物圆盘检查了表面特性，例如表面形态，亲水性和从培养基中吸附血清蛋白的能力。为了在骨和神经组织工程中的潜在应用，已经分别使用大鼠骨髓基质细胞和SPL201细胞进行了体外细胞研究，包括细胞毒性，细胞粘附和具有受控物理性质的交联盘的增殖。此外，使用该模型混合系统已经强调了机械性能（例如表面硬度）在调节细胞反应中的作用。

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