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Evaluation of adhesive properties of poly(propylene fumarate) and fabrication of laminated three-dimensional scaffolds for bone tissue engineering.

机译:聚(富马酸丙二酯)的粘合性能评估和用于骨组织工程的层压三维支架的制造。

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The examination of the adhesive properties of poly(propylene fumarate) (PPF) for application as a hard tissue adhesive and as an adhesive for forming laminated three-dimensional scaffolds for bone tissue engineering was investigated by two sets of experiments.; The adhesive properties of adherends (fabricated with PPF) laminated with PPF were compared with unlaminated controls as well as two well-known hard tissue adhesives, cyanoacrylate and epoxy. By investigating three adhesive parameters (mass, viscosity, and polymer molecular weight), the adhesive properties of PPF were found to match the mechanical properties of unlaminated solid PPF and exceed the adhesive properties of cyanoacrylate and epoxy.; The effect of three scaffold fabrication parameters (porosity, porogen size, and polymer molecular weight) on the tensile properties of laminated scaffolds was investigated. The most significant finding was that a strong bond was formed at the interface between the porous scaffolds independent of scaffold composition.
机译:通过两组实验研究了聚富马酸丙二酯(PPF)作为硬组织粘合剂和用于形成用于骨组织工程的层压三维支架的粘合剂的粘合性能。将与PPF层压的被粘物(由PPF制造)的粘合性能与未层压的对照以及两种众所周知的硬组织粘合剂氰基丙烯酸酯和环氧树脂进行了比较。通过研究三个粘合参数(质量,粘度和聚合物分子量),发现PPF的粘合性能与未层压的固体PPF的机械性能相匹配,并且超过了氰基丙烯酸酯和环氧树脂的粘合性能。研究了三个脚手架制造参数(孔隙度,致孔剂尺寸和聚合物分子量)对层压脚手架拉伸性能的影响。最重要的发现是,在多孔支架之间的界面处形成了牢固的键,与支架的组成无关。

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