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首页> 外文期刊>Biomacromolecules >Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography: Effects of Resin Formulations and Laser Parameters
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Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography: Effects of Resin Formulations and Laser Parameters

机译：立体光刻技术制备聚富马酸丙二醇酯骨组织工程支架：树脂配方和激光参数的影响

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Stereolithography using photo-cross-linkable polymeric biomaterials is an effective technique for fabricating highly complex three-dimensional (3D) scaffolds with controlled microstructures for tissue engineering applications. In this study, we have optimized the UV curable polymer solution composition and laser parameters for the stereolithography machine. Poly(propylene fumarate) (PPF) was used as the biomaterial, diethyl fumarate (DEF) was used as the solvent, and bisacrylphosphrine oxide (BAPO) was used as the photoinitiator. Three different weight ratios of PPF/DEF and BAPO contents were characterized by measuring the viscosities and thermal properties of the un-cross-linked solutions and the mechanical properties of the formed scaffolds. After optimizing the resin composition by satisfying both the viscosity limitation and the mechanical requirement, laser parameters such as critical exposure (E_c) and penetration depth (D_p) were determined from the working curve and the relationship between laser speed and energy by measuring the thickness of predesigned windows fabricated in stereolithography with different ranges of E_c and D_p. Three-dimensional scaffolds with various pore sizes, pore shapes, and porosities were designed in computer-aided design (CAD) software and were fabricated in stereolithography. The fabricated scaffolds were characterized by measuring external dimensions, porosities, mean pore sizes, and compressive moduli and were compared to the CAD models. Feature accuracy in the xy-plane was achieved and overcuring of the resin in z-axis was minimized. The stereolithographically fabricated scaffolds with controlled microstructures can be useful in diverse tissue engineering applications.
机译：使用可光交联的聚合物生物材料进行的光刻技术是一种有效的技术，可用于组织工程应用中具有受控微结构的高度复杂的三维（3D）支架的制造。在这项研究中，我们为立体光刻机优化了UV固化聚合物溶液的成分和激光参数。聚富马酸丙二酯（PPF）被用作生物材料，富马酸二乙酯（DEF）被用作溶剂，双丙烯酸氧化膦（BAPO）被用作光引发剂。通过测量未交联溶液的粘度和热性能以及所形成支架的机械性能，对PPF / DEF和BAPO含量的三种不同重量比进行了表征。通过同时满足粘度极限和机械要求来优化树脂成分后，从工作曲线中确定临界曝光（E_c）和穿透深度（D_p）等激光参数，并通过测量激光的厚度确定激光速度与能量之间的关系。预先设计的以立体光刻法制造的窗口，具有不同的E_c和D_p范围。在计算机辅助设计（CAD）软件中设计了具有各种孔尺寸，孔形状和孔隙率的三维支架，并通过立体光刻技术对其进行了制作。通过测量外部尺寸，孔隙率，平均孔径和压缩模量来表征制造的支架，并将其与CAD模型进行比较。实现了xy平面中的特征精度，并且使z轴上树脂的过度固化最小化。具有受控的微结构的立体光刻制造的支架可用于多种组织工程应用中。

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