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首页> 外文期刊>International Journal of Polymer Science >Effects of Composite Formulation on Mechanical Properties of Biodegradable Poly(Propylene Fumarate)/Bone Fiber Scaffolds
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Effects of Composite Formulation on Mechanical Properties of Biodegradable Poly(Propylene Fumarate)/Bone Fiber Scaffolds

机译：复合配方对可生物降解的富马酸丙二醇酯/骨纤维支架力学性能的影响

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摘要

The objective of our paper was to determine the effects of composite formulation on the compressive modulus and ultimate strength of a biodegradable, in situ polymerizable poly(propylene fumarate) (PPF) and bone fiber scaffold. The following parameters were investigated: the incorporation of bone fibers (either mineralized or demineralized), PPF molecular weight, N-vinyl pyrrolidinone (NVP) crosslinker amount, benzoyl peroxide (BP) initiator amount, and sodium chloride porogen amount. Eight formulations were chosen based on a resolution III two-level fractional factorial design. The compressive modulus and ultimate strength of these formulations were measured on a materials testing machine. Absolute values for compressive modulus varied from 21.3 to 271 MPa and 2.8 to 358 MPa for dry and wet samples, respectively. The ultimate strength of the crosslinked composites varied from 2.1 to 20.3 MPa for dry samples and from 0.4 to 16.6 MPa for wet samples. Main effects of each parameter on the measured property were calculated. The incorporation of mineralized bone fibers and an increase in PPF molecular weight resulted in higher compressive modulus and ultimate strength. Both mechanical properties also increased as the amount of benzoyl peroxide increased or the NVP amount decreased in the formulation. Sodium chloride had a dominating effect on the increase of mechanical properties in dry samples but showed little effects in wet samples. Demineralization of bone fibers led to a decrease in the compressive modulus and ultimate strength. Our results suggest that bone fibers are appropriate as structural enforcement components in PPF scaffolds. The desired orthopaedic PPF scaffold might be obtained by changing a variety of composite formulation parameters.
机译：本文的目的是确定复合制剂对可生物降解的原位可聚合聚富马酸丙二酯（PPF）和骨纤维支架的压缩模量和极限强度的影响。研究了以下参数：骨纤维（矿化的或软化的）的掺入，PPF分子量，N-乙烯基吡咯烷酮（NVP）交联剂的量，过氧化苯甲酰（BP）引发剂的量和氯化钠致孔剂的量。基于分辨率III两级分数阶乘设计选择了八种配方。这些配方的压缩模量和极限强度在材料测试机上测量。干和湿样品的压缩模量绝对值分别从21.3至271 MPa和2.8至358 MPa不等。干样品的交联复合材料的极限强度在2.1到20.3 MPa之间，湿样品的极限强度在0.4到16.6 MPa之间。计算了每个参数对测量特性的主要影响。矿化骨纤维的掺入和PPF分子量的增加导致更高的压缩模量和极限强度。当制剂中过氧化苯甲酰的量增加或NVP的量减少时，两种机械性能也增加。氯化钠对干燥样品的机械性能提高具有主要作用，但对湿样品几乎没有影响。骨纤维的脱矿质导致压缩模量和极限强度的降低。我们的结果表明，骨纤维适合作为PPF支架中的结构增强成分。所需的整形外科PPF支架可通过更改各种复合配方参数来获得。

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