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首页> 外文期刊>Journal of biomedical materials research, Part A >Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering.
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Degradation and biocompatibility of a poly(propylene fumarate)-based/alumoxane nanocomposite for bone tissue engineering.

机译：用于骨组织工程的聚（富马酸丙二酯）/铝氧烷纳米复合材料的降解和生物相容性。

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In this work, we evaluated the in vitro cytotoxicity and in vivo biocompatibility of a novel poly(propylene fumarate) (PPF)-based/alumoxane nanocomposite for bone tissue engineering applications. The incorporation of functionalized alumoxane nanoparticles into the PPF-based polymer was previously shown to significantly increase the material's flexural mechanical properties. In the current study, samples underwent accelerated in vitro degradation to allow the study of biological responses to these materials over the course of their degradation on a shortened timescale. The polymer, a macrocomposite composed of the polymer and micron-sized particles, and the nanocomposite were evaluated at three stages of degradation for in vitro cytotoxicity with a fibroblast cell line and in vivo soft-tissue response after 3 and 12 weeks of implantation in adult goats. All three material groups experienced mass loss during degradation, but the nanocomposite group eroded significantly faster than the other groups. Nondegraded materials demonstrated minimal cytotoxicity and a minor inflammatory response in soft tissue. On the contrary, predegraded samples elicited more pronounced responses, though these were due to the increase in surface area, surface roughness, and fragmentation associated with the degradation process. The presence of alumoxane nanoparticles in the PPF-based nanocomposite did not significantly affect its cytotoxicity or biocompatibility. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007.
机译：在这项工作中，我们评估了用于骨组织工程应用的新型聚（富马酸丙二酯）（PPF）/铝氧烷纳米复合材料的体外细胞毒性和体内生物相容性。先前已证明将官能化的铝氧烷纳米颗粒掺入到基于PPF的聚合物中可以显着提高材料的弯曲机械性能。在当前的研究中，样品经历了加速的体外降解，从而可以在较短的时间范围内研究这些材料在降解过程中的生物学反应。在成人植入第3周和第12周后，在降解的三个阶段评估了该聚合物，由聚合物和微米级颗粒组成的大复合材料以及纳米复合材料的体外成纤维细胞系细胞毒性和体内软组织反应山羊。这三个材料组在降解过程中都经历了质量损失，但纳米复合材料组的腐蚀速度明显快于其他组。未降解的材料在软组织中显示出最小的细胞毒性和较小的炎症反应。相反，尽管是由于表面积增加，表面粗糙度增加以及与降解过程相关的破碎，但预降解的样品引起了更明显的响应。基于PPF的纳米复合材料中铝氧烷纳米颗粒的存在不会显着影响其细胞毒性或生物相容性。 （c）2007年Wiley Periodicals，Inc.《生物医学物质研究》，2007年。

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