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首页> 外文期刊>Journal of biomedical materials research, Part A >Fabrication and in vitro degradation of porous fumarate-based polymer/alumoxane nanocomposite scaffolds for bone tissue engineering.
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Fabrication and in vitro degradation of porous fumarate-based polymer/alumoxane nanocomposite scaffolds for bone tissue engineering.

机译：用于骨组织工程的多孔富马酸酯基聚合物/铝氧烷纳米复合支架的制备和体外降解。

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In this work, the fabrication and in vitro degradation of porous fumarate-based/alumoxane nanocomposites were evaluated for their potential as bone tissue engineering scaffolds. The biodegradable polymer poly (propylene fumarate)/propylene fumarate-diacrylate (PPF/PF-DA), a macrocomposite composed of PPF/PF-DA and boehmite microparticles, and a nanocomposite composed of PPF/PF-DA and surface-modified alumoxane nanoparticles were used to fabricate porous scaffolds by photo-crosslinking and salt-leaching. Scaffolds then underwent 12 weeks of in vitro degradation in phosphate buffered saline at 37 degrees C. The presence of boehmite microparticles and alumoxane nanoparticles in the polymer inhibited scaffold shrinkage during crosslinking. Furthermore, the incorporation of alumoxane nanoparticles into the polymer limited salt-leaching, perhaps due to tighter crosslinking within the nanocomposite. Analysis of crosslinking revealed that the acrylate and overall double bond conversions in the nanocomposite were higher than in the PPF/PF-DA polymer alone, though these differences were not significant. During 12 weeks of in vitro degradation, the nanocomposite lost 5.3% +/- 2.4% of its mass but maintained its compressive mechanical properties and porous architecture. The addition of alumoxane nanoparticles into the fumarate-based polymer did not significantly affect the degradation of the nanocomposite compared with the other materials in terms of mass loss, compressive properties, and porous structure. These results demonstrate the feasibility of fabricating degradable nanocomposite scaffolds for bone tissue engineering by photo-crosslinking and salt-leaching mixtures of fumarate-based polymers, alumoxane nanoparticles, and salt microparticles.
机译：在这项工作中，评估了基于富马酸酯的多孔/铝氧烷纳米复合材料的制备和体外降解的潜力，这些复合物可作为骨组织工程支架。可生物降解的聚合物聚（富马酸丙烯）/富马酸二丙烯酸丙二酯（PPF / PF-DA），由PPF / PF-DA和勃姆石微粒组成的大分子复合物，以及由PPF / PF-DA和表面改性的铝氧烷纳米粒子组成的纳米复合物用光交联和盐浸法制备多孔支架。然后在37摄氏度的磷酸盐缓冲盐水中对支架进行12周的体外降解。聚合物中勃姆石微粒和铝氧烷纳米颗粒的存在抑制了交联过程中支架的收缩。此外，铝氧烷纳米颗粒结合到聚合物中限制了盐的浸出，这可能是由于纳米复合材料内更紧密的交联所致。交联分析表明，纳米复合材料的丙烯酸酯和整体双键转化率高于单独的PPF / PF-DA聚合物，尽管这些差异并不明显。在12周的体外降解过程中，纳米复合材料的质量损失了5.3％+/- 2.4％，但仍保持了其压缩机械性能和多孔结构。在质量损失，压缩性能和多孔结构方面，与其他材料相比，将铝氧烷纳米颗粒添加到富马酸酯基聚合物中不会显着影响纳米复合材料的降解。这些结果证明了通过富马酸酯基聚合物，铝氧烷纳米颗粒和盐微粒的光交联和盐浸混合物制造用于骨组织工程的可降解纳米复合材料支架的可行性。

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