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首页> 外文期刊>Biomacromolecules >Photo-Cross-Linked Hybrid Polymer Networks Consisting of Poly(propylene fumarate) and Poly(caprolactone fumarate): Controlled Physical Properties and Regulated Bone and Nerve Cell Responses
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Photo-Cross-Linked Hybrid Polymer Networks Consisting of Poly(propylene fumarate) and Poly(caprolactone fumarate): Controlled Physical Properties and Regulated Bone and Nerve Cell Responses

机译：由聚富马酸丙二酯和富马酸己内酯组成的光交联杂化聚合物网络：受控的物理性质以及受调节的骨和神经细胞反应

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Aiming to achieve suitable polymeric biomaterials with controlled physical properties for hard and soft tissue replacements,we have developed a series of blends consisting of two photo-cross-linkable polymers: polypropylene fumarate (PPF) and polycaprolactone fumarate (PCLF).Physical properties of both un-cross-linked and UV cross-linked PPF/PCLF blends with PPF composition ranging from 0% to 100% have been investigated extensively.It has been found that the physical properties such as thermal,rheological,and mechanical properties could be modulated efficiently by varying the PPF composition in the blends.Thermal properties including glass transition temperature (T_g) and melting temperature (T_m) have been correlated with their rheological and mechanical properties.Surface characteristics such as surface morphology,hydrophilicity,and the capability of adsorbing serum protein from culture medium have also been examined for the cross-linked polymer and blend disks.For potential applications in bone and nerve tissue engineering,in vitro cell studies including cytotoxicity,cell adhesion,and proliferation on cross-linked disks with controlled physical properties have been performed using rat bone marrow stromal cells and SPL201 cells,respectively.In addition,the role of mechanical properties such as surface stiffness in modulating cell responses has been emphasized using this model blend system.
机译：为了获得合适的具有受控物理性质的聚合物生物材料，用于硬组织和软组织的替代，我们开发了一系列共混物，由两种可光交联的聚合物组成：富马酸聚丙烯酸酯（PPF）和富马酸聚己内酯（PCLF）。 PPF组成从0％到100％的未交联和UV交联的PPF / PCLF共混物已被广泛研究。已发现可以有效地调节物理性质，如热，流变和机械性质通过改变共混物中的PPF组成，将包括玻璃化转变温度（T_g）和熔融温度（T_m）在内的热性质与其流变和机械性质相关联。表面特性如表面形态，亲水性和吸附血清蛋白的能力还检查了从培养基中提取的交联聚合物和共混物盘。分别在大鼠和骨髓组织细胞和SPL201细胞中进行了骨和神经组织工程中的离子，体外细胞研究，包括细胞毒性，细胞粘附和在具有受控物理特性的交联磁盘上的增殖。使用这种模型混合系统已经强调了机械性能，例如在调节细胞反应中的表面硬度。

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