• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>other >Deficits in Cue Detection and Intention Retrieval Underlie Prospective Memory Impairment in Schizophrenia
【2h】

Deficits in Cue Detection and Intention Retrieval Underlie Prospective Memory Impairment in Schizophrenia

机译：提示检测和意图检索不足是精神分裂症前瞻性记忆障碍的基础。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Emerging evidence indicates that individuals with schizophrenia (SCZ) may exhibit deficits in prospective memory (ProM), a dissociable and ecologically important aspect of episodic memory entailing the formation, maintenance, and execution of future intentions. The present study aimed to elucidate the component processes of ProM impairment in 41 individuals with SCZ relative to 41 demographically similar healthy comparison (HC) participants. Results revealed that the SCZ group performed worse than HCs on overall ProM, with comparable deficits on time- and event-based ProM trials. In the SCZ cohort, better ProM performance was associated with younger age and less severe negative symptoms. Although a significantly greater number of task substitution and loss of time errors were evident in the SCZ group as compared to HCs, the most prevalent error type in SCZ was characterized by a complete failure to respond to the ProM cue. Importantly, the SCZ and HC groups did not differ on a post-test multiple-choice recognition trial, suggesting adequate formation and maintenance (i.e., retention) of the ProM cue-intention pairing when self-directed monitoring and retrieval demands were minimized. Findings indicate that SCZ is associated with impairment in the cue detection and self-initiated retrieval components of executing future intentions, which is consistent with a possible prefrontostriatal loop neuropathogenesis. Further studies are needed to explore the neurobiological mechanisms of SCZ-associated ProM impairment and the impact of such deficits on daily functioning (e.g., medication compliance).
机译：新兴证据表明，患有精神分裂症（SCZ）的人可能表现出前瞻性记忆（ProM）缺陷，这是一种情景记忆的可分离且具有生态学意义的方面，需要形成，维持和执行未来的意图。本研究旨在阐明41位SCZ患者相对于41位人口统计学上相似的健康比较（HC）参与者的ProM损伤的组成过程。结果显示，SCZ组在总体ProM上的表现比HC差，在基于时间和事件的ProM试验中，其可比性不足。在SCZ队列中，更好的ProM表现与年龄较小和较不严重的阴性症状相关。尽管与HC相比，SCZ组中明显有大量的任务替换和时间错误损失，但SCZ中最普遍的错误类型的特征是完全无法响应ProM提示。重要的是，SCZ和HC组在测试后的多项选择识别试验中没有差异，这表明当自我指导的监测和检索需求降到最低时，ProM提示-意图配对的形成和维持（即保留）充分。结果表明，SCZ与提示检测和执行未来意图的自启动检索组件的损伤有关，这与可能的前额窦环神经病发病机制一致。需要进一步研究以探索SCZ相关的ProM损伤的神经生物学机制以及此类缺陷对日常功能的影响（例如药物依从性）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号