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首页> 美国卫生研究院文献>Bioactive Materials >Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery
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Drug-loaded chitosan film prepared via facile solution casting and air-drying of plain water-based chitosan solution for ocular drug delivery

机译：通过方便的溶液流延和风干的水性壳聚糖溶液的空气干燥制备的载有药物的壳聚糖膜

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Chitosan is a nature-based polymer with low toxicity, excellent biocompatibility and biodegradability. However, the intractable solubility of chitosan in water and most conventional solvents hampers its biomedical applications. Following the dissolution method for dissolving chitosan in plain water developed by us, chitosan was dissolved in ionic liquid followed by overnight freezing at −20 °C and subsequent solvent exchange with plain water at room temperature. In this study, we fabricated a drug-carrying chitosan film via solution casting and air-drying by using the plain water-based chitosan solution. Specifically, brimonidine tartrate (BT), an antiglaucoma drug, was dissolved in the plain-water based solution and used to prepare BT-loaded chitosan film, i.e., chitosan-BT film. The resulting film is transparent, structurally stable, and mucoadhesive. Micro-sized antiglaucoma BT drug crystals form and are well dispersed in the chitosan film. The chitosan-BT film enables BT to have a high corneal permeability with fast drug release kinetics for potential ocular drug delivery.
机译：壳聚糖是一种基于自然的聚合物，具有低毒性，优异的生物相容性和生物降解性。然而，壳聚糖在水和大多数常规溶剂中的难溶性阻碍了其生物医学应用。按照我们开发的将壳聚糖溶解在纯水中的溶解方法，将壳聚糖溶解在离子液体中，然后在-20°C下冷冻过夜，然后在室温下与纯水交换溶剂。在这项研究中，我们使用普通的水基壳聚糖溶液通过溶液浇铸和风干制备了载有药物的壳聚糖膜。具体地，将抗青光眼药物酒石酸溴莫尼定（BT）溶解于普通水基溶液中，并用于制备负载BT的壳聚糖膜，即壳聚糖-BT膜。所得膜是透明的，结构稳定的和粘膜粘附的。微小的抗青光眼BT药物晶体形成并很好地分散在壳聚糖膜中。壳聚糖-BT膜使BT具有较高的角膜通透性和快速的药物释放动力学，可用于潜在的眼部药物递送。

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