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Protein Assays on Organic Electronics: Rational Device and Material Designs for Organic Transistor‐Based Sensors

机译:有机电子产品上的蛋白质分析:基于有机晶体管的传感器的合理设备和材料设计

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摘要

Artificial receptor‐based protein assays have various attractive features such as a long‐term stability, a low‐cost production process, and the ease of tuning the target specificity. However, such protein sensors are still immature compared with conventional immunoassays. To enhance the application potential of synthetic sensing materials, organic field‐effect transistors (OFETs) are some of the suitable platforms for protein assays because of their solution processability, durability, and compact integration. Importantly, OFETs enable the electrical readout of the protein recognition phenomena of artificial receptors on sensing electrodes. Thus, we believe that OFETs functionalized with artificial protein receptors will be a powerful tool for the on‐site analyses of target proteins. In this Minireview, we summarize the recent progress of the OFET‐based protein assays including the rational design strategies for devices and sensing materials.
机译:基于人工受体的蛋白质测定具有多种吸引人的功能,例如长期稳定性,低成本生产过程以及易于调整靶标特异性。然而,与常规免疫测定法相比,这种蛋白质传感器仍不成熟。为了提高合成感测材料的应用潜力,有机场效应晶体管(OFET)由于其溶液的可加工性,耐用性和紧凑的集成性而成为蛋白质测定的一些合适平台。重要的是,OFET可以电读出传感电极上人工受体的蛋白质识别现象。因此,我们相信用人工蛋白受体功能化的OFETs将成为现场分析靶蛋白的有力工具。在此Minireview中,我们总结了基于OFET的蛋白质测定的最新进展,包括设备和传感材料的合理设计策略。

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