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首页> 美国卫生研究院文献>Clinical Nutrition Research >Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Enzyme Activities in Growing Rats Fed High Fat Diet
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Effects of Isoflavone Supplementation on Lipid Profiles and Antioxidant Enzyme Activities in Growing Rats Fed High Fat Diet

机译：补充异黄酮对高脂饮食喂养的成年大鼠血脂和抗氧化酶活性的影响

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The purpose of this study was to investigate the effects of isoflavone on serum lipids and antioxidant enzymes activities in growing rats fed high lard diet. Twenty four female Sprague-Dawley rats (body weight 50–60 g) were divided into three groups, control, high fat (HF, lard 200 g/kg diet) and high fat + isoflavone (HFI, lard 200 g/kg diet + isoflavone 310.9 mg/kg diet) for 4 weeks. The results of study indicated that body weight gain was not different by isoflavone diet. Mean intake was significantly lower in HF group and HFI group than control group. Food efficiency ratio was significantly higher in HF group and HFI group than control group. The level of serum triglyceride and total cholesterol were significantly lower in HFI group than control group and HF group. The level of high-density lipoprotein cholesterol, was significantly higher in control group than HF group and HFI group. The level of low-density lipoprotein cholesterol was not significantly different by experimental diets, but atherogenic index (AI) was significantly lower in control group and HFI group than HF group. Contents of total cholesterol and triglyceride in liver tissues were found to be insignificant. The concentration of lipid peroxidation, malondialdehyde was significantly lower in control groups and HFI group than HF group. And antioxidant enzymes in liver tissue were not significantly different by lard and isoflavone supplemented diets. In conclusion, it seems possible that isoflavone supplemented high fat diet may produce positive results on level of serum triglyceride, serum total cholesterol, AI and concentration of malondialdyhyde.
机译：这项研究的目的是研究异黄酮对高猪油饮食喂养的成年大鼠血清脂质和抗氧化酶活性的影响。将二十四只雌性Sprague-Dawley大鼠（体重50-60 g）分为三组，对照组，高脂（HF，猪油200 g / kg饮食）和高脂+异黄酮（HFI，猪油200 g / kg饮食+异黄酮310.9 mg / kg饮食）持续4周。研究结果表明，异黄酮饮食对体重增加没有影响。 HF组和HFI组的平均摄入量明显低于对照组。 HF组和HFI组的食物效率比显着高于对照组。 HFI组的血清甘油三酯和总胆固醇水平明显低于对照组和HF组。对照组的高密度脂蛋白胆固醇水平明显高于HF组和HFI组。实验饮食的低密度脂蛋白胆固醇水平无明显差异，但对照组和HFI组的动脉粥样硬化指数（AI）显着低于HF组。肝脏组织中总胆固醇和甘油三酸酯含量微不足道。对照组和HFI组的脂质过氧化，丙二醛浓度明显低于HF组。猪油和异黄酮补充饮食对肝脏组织中抗氧化酶的影响无明显差异。总之，补充异黄酮的高脂饮食在血清甘油三酸酯水平，血清总胆固醇，AI和丙二醛浓度方面可能产生积极的结果。

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