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首页> 美国卫生研究院文献>Food Science Nutrition >Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats
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Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats

机译：日粮中姬松茸饮食通过PI3K / Akt信号通路增强葡萄糖稳态的作用在STZ诱导的糖尿病大鼠中

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摘要

Murrill (ABM) is an edible fungus. This study investigated the protective role of ABM fruiting body against streptozotocin (STZ)‐induced diabetic rats. After 4 weeks of ABM supplement, glucose homeostasis was improved in diabetic rats. Quantitative real‐time and Western blot analyses suggested that ABM could promote the gene and protein expression level of insulin receptor, pyruvate dehydrogenase kinase, phospho‐kinase B, kinase B, phosphatidylinositol 3‐kinase, insulin receptor substrate 1, glucose transporter‐4, and glutamine synthetase, while inhibiting the expression of glycogen synthase kinase 3β and c‐jun N‐terminal kinase 1 and 2. According to multivariate and univariate statistical analysis, liver metabolite profiles of the normal and diabetic rats fed basal and experimental diet were clearly separated. The differential liver metabolites from diabetic rats fed basal and ABM diet‐related pathways including the glycolysis pathway, pentose phosphate pathway, tricarboxylic acid cycle, and oxidative phosphorylation were analyzed. A total of 18 potential biomarker metabolites were identified as differential biomarkers associated with ABM supplement diet.
机译：Murrill（ABM）是一种食用菌。这项研究调查了ABM子实体对链脲佐菌素（STZ）诱导的糖尿病大鼠的保护作用。补充ABM 4周后，糖尿病大鼠的葡萄糖稳态得到改善。实时定量和蛋白质印迹分析表明，ABM可以促进胰岛素受体，丙酮酸脱氢酶激酶，磷酸激酶B，激酶B，磷脂酰肌醇3激酶，胰岛素受体底物1，葡萄糖转运蛋白4，和谷氨酰胺合成酶，同时抑制糖原合酶激酶3β和c-jun N-末端激酶1和2的表达。根据多变量和单变量统计分析，基础饮食和实验饮食的正常和糖尿病大鼠的肝脏代谢特征已明确区分。分析了与基础和ABM饮食有关的途径（包括糖酵解途径，戊糖磷酸途径，三羧酸循环和氧化磷酸化）的糖尿病大鼠的差异肝脏代谢产物。共有18种潜在的生物标志物代谢物被鉴定为与ABM补充食品相关的生物标志物。

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