• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>International Journal of Molecular Sciences >A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets
【2h】

A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets

机译：炎症和免疫在原发性高血压中的作用-使用Petri网建模和分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based model and analyzed it. The analysis was based mainly on t-invariants, knockouts of selected fragments of the net and its simulations. The blockade of the renin-angiotensin (RAA) system revealed that the most significant effect on the emergence of essential hypertension has RAA activation. This blockade affects: (1) the formation of angiotensin II, (2) inflammatory process (by influencing C-reactive protein (CRP)), (3) the initiation of blood coagulation, (4) bradykinin generation via the kallikrein-kinin system, (5) activation of lymphocytes in hypertension, (6) the participation of TNF alpha in the activation of the acute phase response, and (7) activation of NADPH oxidase—a key enzyme of oxidative stress. On the other hand, we found that the blockade of the activation of the RAA system may not eliminate hypertension that can occur due to disturbances associated with the osmotically independent binding of Na in the interstitium. Moreover, we revealed that inflammation alone is not enough to trigger primary hypertension, but it can coexist with it. We believe that our research may contribute to a better understanding of the pathology of hypertension. It can help identify potential subprocesses, which blocking will allow better control of essential hypertension.
机译：最近的研究表明，先天性和适应性免疫系统以及低度炎症可能在原发性高血压中起重要作用。在这项工作中，为了验证所选因素对原发性高血压发展的重要性，我们创建了一个基于Petri网的模型并对其进行了分析。该分析主要基于t不变量，选定网段的敲除及其模拟。肾素-血管紧张素（RAA）系统的阻断显示，对原发性高血压的出现最显着的作用是激活了RAA。此封锁影响：（1）血管紧张素II的形成，（2）炎症过程（通过影响C反应蛋白（CRP）），（3）凝血的起始，（4）通过激肽释放酶激肽系统产生缓激肽；（5）高血压中淋巴细胞的活化；（6）TNFα参与急性期反应的活化；（7）NADPH氧化酶（一种氧化应激的关键酶）的活化。另一方面，我们发现对RAA系统激活的封锁可能无法消除高血压，而高血压可能是由于与组织间Na的渗透性独立结合有关的干扰引起的。此外，我们发现仅炎症不足以引发原发性高血压，但可以与之共存。我们相信我们的研究可能有助于更好地了解高血压的病理。它可以帮助识别潜在的子过程，这些子过程可以更好地控制原发性高血压。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号