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首页> 美国卫生研究院文献>Journal of Clinical Biochemistry and Nutrition >Moderate intake of aspartame and sucralose with meals but not fructose does not exacerbate energy and glucose metabolism in estrogen-deficient rats
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Moderate intake of aspartame and sucralose with meals but not fructose does not exacerbate energy and glucose metabolism in estrogen-deficient rats

机译：随餐适量摄入阿斯巴甜和三氯蔗糖而非果糖不会加剧雌激素缺乏大鼠的能量和葡萄糖代谢

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Both nutritive and non-nutritive sweeteners may influence energy and glucose metabolism differently. The hypothesis that sucrose, fructose, aspartame, and sucralose intake differently modulate energy and glucose metabolism was tested in an estrogen-deficient animal model. At 30 min after giving aspartame and sucralose (10 mg/kg body weight), an oral glucose tolerance test (OGTT) was conducted with glucose, sucrose, and fructose in ovariectomized (OVX) rats. After OGTT, they were continuously fed high fat diets including either 10% corn starch (Control), 10% sucrose (Sucrose), 10% fructose (Fructose), 0.05% aspartame + 9.95% starch (Aspartame) or 0.05% sucralose + 9.95% starch (Sucralose) for 8 week. During 30 min after acute administration of aspartame and sucralose, serum glucose concentrations increased despite slightly increased serum insulin levels before glucose infusion. However, glucose tolerance was not significantly different among the groups. In chronic study, serum glucose concentrations were lowest and insulin highest at the overnight-fasted state in Aspartame and Sucralose. Postprandial serum glucagon-like peptide-1 (GLP-1) and insulin levels were higher in Aspartame and Sucralose than Control. Hepatic insulin signaling (pAkt → pGSK-3β) and phosphoenolpyruvate carboxykinase (PEPCK) expression were lower in Sucralose and Aspartame than the Fructose. Serum acetate levels produced by gut microbiota were higher were lower in the fructose group than Aspartame and Sucralose groups. In conclusion, aspartame and sucralose with a meal might be preferable sweeteners to fructose and sucrose in estrogen deficient rats, and possibly post-menopausal women; however, this needs to be confirmed in human studies.
机译：营养性和非营养性甜味剂均可能对能量和葡萄糖代谢产生不同的影响。在雌激素缺乏的动物模型中检验了蔗糖，果糖，阿斯巴甜和三氯蔗糖摄入量不同地调节能量和葡萄糖代谢的假说。给予阿斯巴甜和三氯蔗糖（10 mg / kg体重）后30分钟，对去卵巢（OVX）大鼠的葡萄糖，蔗糖和果糖进行口服葡萄糖耐量测试（OGTT）。在进行OGTT后，他们持续喂食高脂饮食，包括10％玉米淀粉（对照），10％蔗糖（蔗糖），10％果糖（果糖），0.05％阿斯巴甜+ 9.95％淀粉（阿斯巴甜）或0.05％三氯蔗糖+ 9.95 ％淀粉（三氯蔗糖）8周。在急性给予阿斯巴甜和三氯蔗糖后30分钟内，尽管在输注葡萄糖前血清胰岛素水平略有增加，但血清葡萄糖浓度却有所增加。但是，各组之间的葡萄糖耐量没有显着差异。在慢性研究中，阿斯巴甜和三氯蔗糖在过夜禁食状态下的血糖浓度最低，胰岛素最高。阿斯巴甜和三氯蔗糖的餐后血清胰高血糖素样肽-1（GLP-1）和胰岛素水平高于对照组。三氯蔗糖和阿斯巴甜中的肝胰岛素信号（pAkt→pGSK-3β）和磷酸烯醇丙酮酸羧激酶（PEPCK）的表达低于果糖。果糖组的肠道菌群产生的血清乙酸水平高于阿斯巴甜和三氯蔗糖组。总之，在雌激素缺乏的大鼠以及绝经后的妇女中，阿斯巴甜和三氯蔗糖一起进餐可能是比果糖和蔗糖更好的甜味剂。但是，这需要在人体研究中得到证实。

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