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首页> 外文期刊>Journal of clinical biochemistry and nutrition. >Moderate intake of aspartame and sucralose with meals, but not fructose, does not exacerbate energy and glucose metabolism in estrogen deficient rats
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Moderate intake of aspartame and sucralose with meals, but not fructose, does not exacerbate energy and glucose metabolism in estrogen deficient rats

机译：适度摄入阿斯巴甜和三氯蔗糖与膳食，但不是果糖，不会加剧雌激素缺陷大鼠的能量和葡萄糖代谢

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摘要

Both nutritive and non-nutritive sweeteners may influence energy and glucose metabolism differently. The hypothesis that sucrose, fructose, aspartame, and sucralose intake differently modulate energy and glucose metabolism was tested in an estrogen-deficient animal model. At 30 min after giving aspartame and sucralose (10 mg/kg body weight), an oral glucose tolerance test (OGTT) was conducted with glucose, sucrose, and fructose in ovariectomized (OVX) rats. After OGTT, they were continuously fed high fat diets including either 10% corn starch (Control), 10% sucrose (Sucrose), 10% fructose (Fructose), 0.05% aspartame + 9.95% starch (Aspartame) or 0.05% sucralose + 9.95% starch (Sucralose) for 8 week. During 30 min after acute administration of aspartame and sucralose, serum glucose concentrations increased despite slightly increased serum insulin levels before glucose infusion. However, glucose tolerance was not significantly different among the groups. In chronic study, serum glucose concentrations were lowest and insulin highest at the overnight-fasted state in Aspartame and Sucralose. Postprandial serum glucagon-like peptide-1 (GLP-1) and insulin levels were higher in Aspartame and Sucralose than Control. Hepatic insulin signaling (pAkt -> pGSK-3 beta) and phosphoenolpyruvate carboxykinase (PEPCK) expression were lower in Sucralose and Aspartame than the Fructose. Serum acetate levels produced by gut microbiota were higher were lower in the fructose group than Aspartame and Sucralose groups. In conclusion, aspartame and sucralose with a meal might be preferable sweeteners to fructose and sucrose in estrogen deficient rats, and possibly post-menopausal women; however, this needs to be confirmed in human studies.
机译：营养和非营养甜味剂均可能不同地影响能量和葡萄糖代谢。假设在雌激素缺乏的动物模型中测试了蔗糖，果糖，阿斯巴甜和三氯蔗糖摄入不同调节能量和葡萄糖代谢。在给予阿斯巴甜和三氯蔗糖（10mg / kg体重）后30分钟，用卵巢切除（OVX）大鼠的葡萄糖，蔗糖和果糖进行口腔葡萄糖耐量试验（OGTT）。 OGTT后，它们不断喂养高脂肪饮食，包括10％玉米淀粉（对照），10％蔗糖（蔗糖），10％果糖（果糖），0.05％阿斯巴甜+ 9.95％淀粉（阿斯巴甜）或0.05％Sucralose + 9.95 ％淀粉（三氯蔗糖）8周。在急性施用阿斯巴甜和三氯蔗糖后30分钟内，尽管葡萄糖输注前血清胰岛素水平略微增加，但血清葡萄糖浓度增加。然而，葡萄糖耐受性在组中没有显着差异。在慢性研究中，血清葡萄糖浓度在阿斯巴甜和三氯蔗糖的过夜禁食状态下是最低和胰岛素最高的。在阿斯巴甜和三氯蔗糖比对照中均高于对照，血清血清胰腺苷样肽-1（GLP-1）和胰岛素水平较高。肝胰岛素信号（PAKT - > PGSK-3β）和磷酸丙酮醛酸胆肽（PEPCK）表达在三氯蔗糖和阿斯巴甜比果糖中较低。肠道微生物产生的血清乙酸盐水平在果糖组中较高，比阿斯巴甜和三氯蔗糖基团更低。总之，阿斯巴甜和三氯蔗糖与膳食可能是雌激素缺乏大鼠的果糖和蔗糖的甜味剂，并且可能是绝经后妇女;然而，这需要在人类研究中确认。

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