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首页> 美国卫生研究院文献>Journal of Clinical Medicine >Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease
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Associations between the Quality of Life and Nasal Polyp Size in Patients Suffering from Chronic Rhinosinusitis without Nasal Polyps with Nasal Polyps or Aspirin-Exacerbated Respiratory Disease

机译：无鼻息肉鼻息肉或阿司匹林加重呼吸系统疾病的慢性鼻-鼻窦炎患者的生活质量与鼻息肉大小之间的关系

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Chronic rhinosinusitis (CRS) is a common disease that substantially impairs the quality of life (QoL). Here, we aimed to assess patients’ QoL in different subtypes of CRS and correlated this with nasal polyp size to improve the clinical understanding of the burden of disease. In this retrospective single-center study, 107 patients with the following diagnoses were analyzed: CRS without nasal polyps (CRSsNP), CRS with nasal polyps (CRSwNP), or aspirin-exacerbated respiratory disease (AERD). Sino-Nasal Outcome Test-20 German Adapted Version (SNOT-20 GAV) scores and their correlation with endoscopic Total Polyp Scores (TPS) were evaluated. The mean SNOT-20 GAV scores were highest in patients with AERD (AERD = 43.4, CRSwNP = 36.3, CRSsNP = 30.9). A statistically significant correlation of total SNOT-20 GAV score with TPS was observed in CRSwNP patients (r = 0.3398, = 0.0195), but not in AERD patients (r = 0.2341, = 0.1407). When analyzing single SNOT-20 parameters, a strong correlation with TPS was observed for blockage/congestion of the nose, particularly in AERD patients (r = 0.65, < 0.0001). The impact of nasal polyp size on the QoL differs amongst the subgroups of CRS. Nasal symptoms have the greatest impact on QoL in patients suffering from AERD. CRSwNP and AERD patients should be separately analyzed in clinical investigations and interpretations due to significant differences in QoL.
机译：慢性鼻－鼻窦炎（CRS）是一种普遍损害生活质量（QoL）的常见疾病。在这里，我们旨在评估不同CRS亚型患者的QoL，并将其与鼻息肉大小相关联，以提高对疾病负担的临床认识。在这项回顾性单中心研究中，分析了107例具有以下诊断的患者：无鼻息肉的CRS（CRSsNP），有鼻息肉的CRS（CRSwNP）或阿司匹林加重呼吸道疾病（AERD）。评估了鼻腔结果测试20德国适应版（SNOT-20 GAV）评分及其与内镜总息肉评分（TPS）的相关性。 AERD患者的平均SNOT-20 GAV得分最高（AERD = 43.4，CRSwNP = 36.3，CRSsNP = 30.9）。在CRSwNP患者中观察到总SNOT-20 GAV评分与TPS有统计学意义的相关性（r = 0.3398，= 0.0195），而在AERD患者中则没有（r = 0.2341，= 0.1407）。分析单个SNOT-20参数时，观察到与TPS在鼻子阻塞/充血方面有很强的相关性，特别是在AERD患者中（r = 0.65，<0.0001）。鼻息肉大小对QoL的影响在CRS的亚组之间有所不同。鼻部症状对AERD患者的QoL影响最大。由于QoL的显着差异，应在临床研究和解释中分别分析CRSwNP和AERD患者。

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